Volume 13, Issue 3 (May-Jun 2019)                   mljgoums 2019, 13(3): 35-39 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Habibi Juybari M, Pordeli H, Mikaeili S. Synthesis, Characterization and Antibacterial Activity of Some New Neocuproine Schiff Bases. mljgoums 2019; 13 (3) :35-39
URL: http://mlj.goums.ac.ir/article-1-1211-en.html
Synthesis, Characterization and Antibacterial Activity of Some New Neocuproine Schiff Bases
Mohammad Habibi Juybari 1, Hamidreza Pordeli2 , Saeid Mikaeili2
1- Department of Chemistry, Gorgan Branch Islamic Azad University, Gorgan, Iran
2- Department of Microbiology, Gorgan Branch Islamic Azad University, Gorgan, Iran
Abstract:   (5003 Views)
ABSTRACT
            Background and Objectives: Schiff base ligands are prepared via the condensation reaction of 1, 10- dimethyl–phenantroline aldehyde derivative with some nitrogen donor ligands, such as benzene ring that have different functional groups (-OH, -SH, -OCH3,-CH2OH, -Br) in acetonitrile. Recent studies suggest that Schiff bases might have antibacterial activity. Therefore, we aimed to synthesize new Schiff base complexes and evaluate their antibacterial activity against a number of Gram-positive and Gram-negative bacteria.
            Methods: Schiff base ligands and their complexes were characterized by mass spectrometry, infrared spectroscopy and nuclear magnetic resonance spectroscopy. The in vitro antibacterial activity of the Schiff base ligands and metal ions against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was evaluated by determining minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) using the broth dilution method.
            Results: All synthesized Schiff bases exhibited favorable antibacterial activity against the tested microorganism, but the antibacterial effect of compounds 3OH and 3SH was more significant than that of other compounds.
            Conclusion: Compound 3EOH has favorable antibacterial activity against the tested bacteria.
            Keywords: Schiff bases, antibacterial effect, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa.
Keywords: Schiff bases, antibacterial effect, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa
Full-Text [PDF 525 kb]   (946 Downloads)    
Research Article: Original Paper | Subject: Sport Physiology
Received: 2019/04/24 | Accepted: 2019/04/24 | Published: 2019/04/24 | ePublished: 2019/04/24
References
1. Cleiton M da Silva , Daniel L da Silva , Luzia V Modolo , Rosemeire B Alves , Maria A de Resende , Cleide VB Martins. Schiff bases: A short review of their antimicrobial activities. Journal of Advanced Research. 2011; 2 [DOI:10.1016/j.jare.2010.05.004]
2. Meenachi M, Chitra S. Review of Chemistry and Biological Importance of Schiff Base. International Journal of Scientific Research and Reviews. 2014; 3(1): 8-18.
3. Malladi S, Isloor AM, Isloor S, Akhila DS, Fun HK. Synthesis, Characterization and Antibacterial activity of some new pyrazole based Schiff bases. Arabian Journal of Chemistry. 2013; 6(3): 335-40. [DOI:10.1016/j.arabjc.2011.10.009]
4. Vijesh AM, Isloor AM, Prabhu V, Ahmad S, Malladi, S. Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles. Eur Journal Med Chem. 2010; 45(11): 5460-4. [DOI:10.1016/j.ejmech.2010.07.048]
5. Schiff H. Mittheilungen aus dem universita¨ tslaboratorium in Pisa: Eine neue reihe organischer basen. Justus Liebigs Ann Chem. 1864; 131(1): 118-9. [DOI:10.1002/jlac.18641310113]
6. Holla BS, Veerendra B, Shivananda MK, Poojary, B. Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles. Eur Journal Med Chem. 2003; 38(7-8): 759-67. [DOI:10.1016/S0223-5234(03)00128-4]
7. Patole J, Shingnapurkar D, Padhye S, Ratledge C. Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents. Bioorganic & Medicinal Chemistry Letters. 2006; 16(6): 1514-7. [DOI:10.1016/j.bmcl.2005.12.035]
8. Shi L, Ge HM, Tan SH, Li HQ, Song YC, Zhu HL, et al. Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. Eur J Med Chem. 2007; 42(4): 558-64. [DOI:10.1016/j.ejmech.2006.11.010]
9. Chandler CJ, Deady LW, Reiss JA. Synthesis of some 2,9-disubstitued- 1,10- phenanthrolines. Journal Hetrocyclic Chem. 1981; 18: 599-601. [DOI:10.1002/jhet.5570180332]
10. Habibi M, Bayat Y, Marandi R, Mehrdadsharif AA, Salahi A. One-pot Synthesis of 4H-Pyran-4-one Carboxaldehyde Derivatives by Using Selenium Dioxide as a Reusable Oxidant. Asian Journal of chemistry. 2012; 24(11): 5239-41.
11. Collee J. Mackie and Mccartney Practical Medical Microbiology. 13th ed.Churchill Livingstone. Edinburgh. 1989.
Add your comments about this article : Your username or Email:
CAPTCHA
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2007 All Rights Reserved | Medical Laboratory Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.