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Volume 18, Issue 1 (Jan-Feb 2024)
mljgoums 2024, 18(1): 23-26 |
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Shirdel Abdolmaleki A, Rafati Zomorodi A, Motamedifar M, Malekzadegan Y. Antimicrobial susceptibility patterns in Escherichia coli isolates from Hospital-acquired urinary tract infections. mljgoums 2024; 18 (1) :23-26
URL: http://mlj.goums.ac.ir/article-1-1521-en.html
URL: http://mlj.goums.ac.ir/article-1-1521-en.html
Abolfazl Shirdel Abdolmaleki1 
, Abolfazl Rafati Zomorodi1 , Mohammad Motamedifar 2, Yalda Malekzadegan3
, Abolfazl Rafati Zomorodi1 , Mohammad Motamedifar 2, Yalda Malekzadegan3
1- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran ,motamedm@sums.ac.ir
3- Department of Microbiology, Saveh University of Medical Sciences, Saveh, Iran
2- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran ,
3- Department of Microbiology, Saveh University of Medical Sciences, Saveh, Iran
Abstract: (893 Views)
Background: Urinary tract infection (UTI) is one of the most common bacterial infections of all ages and sexes. Escherichia coli is reported as the most common predominant pathogen. Urinary tract infection treatment leads to abundant antibiotic application in hospitals and communities, continuously developing multidrug resistance (MDR). This study aimed to determine the sensitivity and resistance pattern to common antibiotics among E. coli isolates from patients with UTIs at Nemazee Hospital in Shiraz.
Methods: This retrospective cross-sectional survey studied 1910 positive urine samples with E. coli bacteria from patients referred to Nemazee Hospital from 2018 to 2019. Antimicrobial susceptibility testing was performed on 12 commonly used antibiotics for UTIs.
Results: A total of 1910 E. coli isolates were gathered during these 2 years. The most highlighted resistance was observed against quinolones and cephalosporins at 86.9% and 89.7%, respectively. Cephalexin (87.9%) and nalidixic acid (86.1%) have shown the lowest activity against E. coli isolates. Also, the highest susceptibility was determined for amikacin (88.3%), nitrofurantoin (76.8%), and gentamicin (70.6%). In addition, 1624 (85%) isolates were MDR.
Conclusion: In conclusion, resistance to antibiotics (such as ciprofloxacin, norfloxacin, tetracycline, cefotaxime, and nitrofurantoin) is increasing. Therefore, it is vital to follow an appropriate antimicrobial stewardship program.
Methods: This retrospective cross-sectional survey studied 1910 positive urine samples with E. coli bacteria from patients referred to Nemazee Hospital from 2018 to 2019. Antimicrobial susceptibility testing was performed on 12 commonly used antibiotics for UTIs.
Results: A total of 1910 E. coli isolates were gathered during these 2 years. The most highlighted resistance was observed against quinolones and cephalosporins at 86.9% and 89.7%, respectively. Cephalexin (87.9%) and nalidixic acid (86.1%) have shown the lowest activity against E. coli isolates. Also, the highest susceptibility was determined for amikacin (88.3%), nitrofurantoin (76.8%), and gentamicin (70.6%). In addition, 1624 (85%) isolates were MDR.
Conclusion: In conclusion, resistance to antibiotics (such as ciprofloxacin, norfloxacin, tetracycline, cefotaxime, and nitrofurantoin) is increasing. Therefore, it is vital to follow an appropriate antimicrobial stewardship program.
Research Article: Research Article |
Subject:
bacteriology
Received: 2022/05/22 | Accepted: 2023/12/5 | Published: 2024/01/21 | ePublished: 2024/01/21
Received: 2022/05/22 | Accepted: 2023/12/5 | Published: 2024/01/21 | ePublished: 2024/01/21
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