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Volume 16, Issue 6 (Special issue (Nov-Dec) 2022)
mljgoums 2022, 16(6): 35-39 |
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Jaykar H, Nagare M, Bhat G. Evaluation of Absolute Neutrophil Count in COVID-19 Patients in a Tertiary Care Hospital. mljgoums 2022; 16 (6) :35-39
URL: http://mlj.goums.ac.ir/article-1-1522-en.html
URL: http://mlj.goums.ac.ir/article-1-1522-en.html
1- Department of Pathology, Maharashtra Institute of Medical Education and Research, Medical College, Talegaon Dabhade, Pune, Maharashtra, India , dr.harshaj@gmail.com
2- Department of Pathology, Maharashtra Institute of Medical Education and Research, Medical College, Talegaon Dabhade, Pune, Maharashtra, India
3- Department of Pathology, Maharashtra Institute of Medical Education and Research, Medical College, Talegaon Dabhade, Pune, Maharashtra, India
2- Department of Pathology, Maharashtra Institute of Medical Education and Research, Medical College, Talegaon Dabhade, Pune, Maharashtra, India
3- Department of Pathology, Maharashtra Institute of Medical Education and Research, Medical College, Talegaon Dabhade, Pune, Maharashtra, India
Abstract: (1369 Views)
Background and objectives: Coronavirus disease 2019 (COVID-19) is a communicable disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical manifestations of COVID-19 vary from asymptomatic to acute respiratory distress syndrome. In severely-ill patients, neutrophil count is significantly increased. This study aimed to evaluate absolute neutrophil count (ANC) in patients with COVID-19 and healthy individuals.
Methods: This retrospective, cross-sectional study was carried out on patients admitted to the outpatient department of OBGY Rural Hospital (Maharashtra, India) from April 2021 to June 2021. A peripheral venous blood sample (3 ml) was taken from 143 patients with COVID-19 and 143 healthy controls. The blood samples were analyzed using a fully automated blood cell counter for the estimation of complete blood count. A peripheral blood smear was prepared and stained with Leishman stain for evaluation of morphological changes.
Results: The ANC of COVID-19 patients was significantly higher than that of healthy control subjects (p=0.00001). Toxic granules (48.9%) were the most common morphological neutrophil abnormality, followed by hypolobation, hypogranulation, Pseudo-Pelger-Huet anomaly (20.9%), and shift to left with the presence of immature myeloid series cells.
Conclusion: High ANC along with morphological changes in neutrophils could be used as a simple and inexpensive surrogate marker of COVID-19 and its severity.
Methods: This retrospective, cross-sectional study was carried out on patients admitted to the outpatient department of OBGY Rural Hospital (Maharashtra, India) from April 2021 to June 2021. A peripheral venous blood sample (3 ml) was taken from 143 patients with COVID-19 and 143 healthy controls. The blood samples were analyzed using a fully automated blood cell counter for the estimation of complete blood count. A peripheral blood smear was prepared and stained with Leishman stain for evaluation of morphological changes.
Results: The ANC of COVID-19 patients was significantly higher than that of healthy control subjects (p=0.00001). Toxic granules (48.9%) were the most common morphological neutrophil abnormality, followed by hypolobation, hypogranulation, Pseudo-Pelger-Huet anomaly (20.9%), and shift to left with the presence of immature myeloid series cells.
Conclusion: High ANC along with morphological changes in neutrophils could be used as a simple and inexpensive surrogate marker of COVID-19 and its severity.
Research Article: Original Paper |
Subject:
Laboratory hematology
Received: 2022/05/22 | Accepted: 2022/08/31 | Published: 2022/11/25 | ePublished: 2022/11/25
Received: 2022/05/22 | Accepted: 2022/08/31 | Published: 2022/11/25 | ePublished: 2022/11/25
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