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mljgoums 2024, 18(3): 16-20 |
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Kaur K. An overview of the production of AmpC and Metallo-β-Lactamase enzymes in Escherichia coli. mljgoums 2024; 18 (3) :16-20
URL: http://mlj.goums.ac.ir/article-1-1548-en.html
URL: http://mlj.goums.ac.ir/article-1-1548-en.html
Lovely Professional University, Phagwara, Punjab, India. , kaurkiran.971997@gmail.com
Abstract: (566 Views)
Escherichia coli is a Gram-negative, rod-shaped bacterium, responsible for 90% of all community-acquired infections and 50% of hospital-acquired infections, with opportunistic infections found in intensive care unit (ICU) patients. The β-lactam antibiotics, which inhibit cell wall synthesis, are known for their high efficacy and broad-spectrum activity. They also have low toxicity and provide long-term effects, making them widely used drugs against Gram-negative bacteria. Bacteria develop resistance to β-lactams primarily through the expression of hydrolytic enzymes, called β-lactamases, which are divided into serine β-lactamases (Classes A, C, and D) and metallo-β-lactamases (Class B), based on their molecular mechanism. This study aimed to clarify the mechanism of action of β-lactams against Gram-negative bacilli and to emphasize the multidrug resistance of cephalosporins and carbapenems to E. coli.
Keywords: Escherichia Coli, Drug Resistance, Microbial, AmpC Beta-Lactamases, Metallo-Beta-Lactamase
Research Article: Review Article |
Subject:
Microbiology
Received: 2022/07/11 | Accepted: 2024/01/24 | Published: 2024/11/12 | ePublished: 2024/11/12
Received: 2022/07/11 | Accepted: 2024/01/24 | Published: 2024/11/12 | ePublished: 2024/11/12
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