Volume 19, Issue 2 (Mar-Apr 2025)                   mljgoums 2025, 19(2): 22-24 | Back to browse issues page


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Karim S, Zahedi M, Mohammadi Z, Poursharifi N, Khorami M, Tatar M. The effect of cigarette smoking on serum homocysteine, folic acid, and vitamin B12 concentrations in patients with cardiovascular diseases. mljgoums 2025; 19 (2) :22-24
URL: http://mlj.goums.ac.ir/article-1-1708-en.html
1- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (742 Views)
Background: Smoking is recognized as a significant risk factor for cardiovascular diseases (CVD), yet its influence on blood levels of homocysteine, folic acid, and vitamin B12 is not well understood. This study aimed to explore how smoking affects these biochemical markers in patients with CVD.
Methods: The study included 88 participants diagnosed with CVD, who were categorized into smokers (n=44) and non-smokers (n=44). Serum concentrations of homocysteine, folic acid, and vitamin B12 were assessed using ELISA. Additionally, blood pressure (both systolic and diastolic) and body mass index (BMI) were recorded.
Results: Smokers showed significantly lower levels of folic acid (22.41 ± 5.95 ng/mL) compared to non-smokers (28.05 ± 4.13 ng/mL, p = 0.000). No significant differences were observed in homocysteine (p = 0.958) or vitamin B12 (p = 0.578) levels between the two groups. A negative correlation was found between folic acid and systolic blood pressure in smokers, while no significant associations were noted among folic acid, vitamin B12, and homocysteine.
Conclusion: In patients with CVD, smoking is linked to significantly lower folic acid levels, which may lead to increased systolic blood pressure. These results underscore the need to monitor folic acid levels in smokers who are at risk for cardiovascular issues.
Full-Text [PDF 318 kb]   (195 Downloads)    
Research Article: Original Paper | Subject: Laboratory Sciences
Received: 2023/08/26 | Accepted: 2023/10/15 | Published: 2025/07/28 | ePublished: 2025/07/28

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.