Distribution of Anti-leptospira Antibodies in the Sera of Patients Suspected Leptospirosis

Roohi, Z,; Moradi Bidhendi, S,; Khaki, P,

Volume 9, Issue 1 (March, April[PERSIAN] 2015) mljgoums 2015, 9(1): 25-31 | Back to browse issues page

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Roohi, Z, Moradi Bidhendi, S, Khaki, P. Distribution of Anti-leptospira Antibodies in the Sera of Patients Suspected Leptospirosis. mljgoums 2015; 9 (1) :25-31
URL: http://mlj.goums.ac.ir/article-1-601-en.html

Distribution of Anti-leptospira Antibodies in the Sera of Patients Suspected Leptospirosis

Roohi, Z¹

, Moradi Bidhendi, S¹

, Khaki, P

1- Leptospira Laboratory Reference, Razi Vaccine & Serum Research Institute, hessarak, Karaj, Iran
2- Leptospira Laboratory Reference, Razi Vaccine & Serum Research Institute, hessarak, Karaj, Iran , s.bidhendi@rvsri.ac.ir

Abstract: (12802 Views)

Abstract Background and Objective: Leptospirosis is a zoonosis infectious disease that is prevalent in tropical and subtropical regions and is caused by the pathogenic serovars of leptospires. Hence, we aimed at investigating the prevalence of antibodies against these bacteria in the blood samples of suspected leptospirosis. Material and Methods: the human serum samples (N = 130) were obtained from patients clinically suspected leptospirosis. The Serum level of IgM antibodies were studied by ELISA kit (PrioCHECK) in Razi Vaccine and Serum Research Institute (Karaj), 2011-2012. Results: Anti-leptospira IgM class was observed in 21(16%) samples. The relative distribution of the disease was reported in men (80.95%), women (19.04%), and farmers (30.95%) and in 20-40-year group (57.14%). Contact with contaminated water was the most common cause of infection (52.38%) and fever was the most common sign of Leptospirosis (72.2%). Conclusion: Due to the occurrence of anti-leptospira antibodies in 16% of suspected cases, it is recommended that routine ELISA be done at least in major diagnostic centers. Keywords: Leptospira, Leptospirosis, Human, ELISA

Keywords: Leptospira, Leptospirosis, Human, ELISA

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Research Article: Original Paper |
Received: 2014/12/28 | Accepted: 2014/12/28 | Published: 2014/12/28 | ePublished: 2014/12/28