ABSTRACT

       Background and Objective: Osteoporosis is one of the complications of diabetes. The aim of this study was to determine the impact of resistance training along with Portulaca oleracea supplementation on OPG and NFκB levels (bone markers) in women with type II diabetes.

       Methods: Overall, 28 women with type II diabetes (44 to 60 years old) were randomly and equally assigned into four groups (supplement, training, training-supplement and control). An eight-week resistance training program (three one-hour sessions per week with one repetition maximum) was performed using three types of bands with different resistances, at 40-50% intensity and 50-70% maximum heart rate. P. oleracea seeds were supplemented daily (7.5 grams mixed in yogurt) for eight weeks. The data was analyzed using descriptive statistics, paired t-test and ANOVA.

       Results: After 8 weeks, OPG and NFκB levels in the three groups of supplement, training and training-supplement increased and decreased, respectively. The highest change in both variables was observed in the training-supplement group. Moreover, the level of these two variables in the training-supplement group had significant difference with the controls and other groups (P=0.000).

       Conclusion: As a non-pharmacological therapeutic approach, the regular resistance training and P. oleracea supplementation can increase bone formation markers and reduce bone resorption in women with type II diabetes.