Sepideh Shakeri, Narjes Soltani, Mohammad Reza Javan, Mehrnaz Abdolalian, Hossein Ayatollahi, Seyyede Fatemeh Shams,
Volume 17, Issue 1 (Jan-Feb 2023)
Abstract
Background and objectives: Fanconi anemia (FA) is an autosomal recessive disorder that usually manifest in forms of pancytopenia, hyperpigmentation, and skeletal complications. Mutation in the DNA repair regulatory genes is associated with the development of FA. Examination of chromosomal breakages when chromosomes are exposed to cross-linking agents is a common method of FA diagnosis. This study aimed to evaluate the prevalence and characteristics of patients with FA in Mashhad, northeast of Iran.
Methods: In this study, we evaluated 312 suspected FA patients who had been referred to the laboratory of Ghaem Hospital during 2014-2020. The mitomycin C method was used to identify FA-positive subjects.
Results: After the examinations, 84 patients (26.9%) were cytogenetically positive for FA. Of 84 patients, 48 (57.1%) were male and 36 (42.9%) were female. Thumb abnormality was the most common congenital anomaly (43.2%).
Conclusion: Based on the findings, males are more susceptible to FA, and thumb abnormality is the most common congenital anomaly associated with FA. Combination of clinical manifestations and genetic susceptibility in patients may contribute to a more accurate diagnosis.
Faeze Shahriyari , Seyyede Fatemeh Shams , Mehrnaz Abdolalian , Narjes Soltani , Hashem Honari , Leila Rafaty Javanbakht, Mohammadreza Javan ,
Volume 19, Issue 5 (Sep-Oct 2025)
Abstract
Background: Blood transfusion services are responsible for providing blood products. Knowing the parameters that affect people’s decision to donate blood will help respond to this demand. This study was designed to assess the attitudes and barriers toward blood donation among volunteer donors in Mashhad (Northeast of Iran) during 2014-2015.
Methods: This cross-sectional study was performed in Iranian Blood Transfusion Organization centers in Mashhad. A total of 640 volunteer blood donors, including first-time and frequent donors, attended this study. The questionnaire was designed based on similar studies, and the reliability and validity were controlled. A questionnaire consisting of multiple-choice questions was provided to the participants. SPSS software was used for data analysis. The Student’s t-test was used, and P<0.05 was considered significant.
Results: Among the 640 participants, 80% completed and returned the questionnaire. Of the participants, 474 (92.5%) were male and 38 (7.4%) were female. A total of 114 donors were first-time donors, and the others had donated blood before. The most important motivations for blood donation included altruism: 249 (91.88%) among frequent donors and 76 (85.40%) among first-time donors. Other factors such as social influences also played a role. Lack of time (73.80%) was the most important barrier to blood donation among the first-time donors.
Conclusion: The results showed that the most important motive and barrier for blood donation were altruism and lack of time, respectively. In other words, paying attention to the motivations and barriers of blood donation can play an important role in attracting and retaining blood donors.
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