Showing 3 results for Hashemvarzi
Mehdi Nasiraey, Abdolreza Jafari Chashmi, Seyd Abdollah Hashemvarzi,
Volume 14, Issue 6 (Nov-Dec 2020)
Abstract
Background and objectives: It has been suggested that irisin and fibronectin type III domain-containing protein 5 (FNDC5) can increase energy expenditure, promote weight loss and improve insulin resistance in diabetic patients by affecting white and brown adipose tissues. In this study, we investigate effect of adipose tissue-derived stem cell transplantation and six weeks of aerobic exercise on FNDC5 and irisin levels in streptozotocin-induced diabetic rats.
Methods: Forty-eight rats (weighing 220-240 g and aged nine weeks) were divided into six groups of control, sham, diabetes control, diabetes + exercise, diabetes + stem cell and diabetes+ exercise + stem cell. The exercise group ran on running wheel at intensity of 60-70% VO2max, five days a week for six weeks. Next, 1.56 × 106 stem cells extracted from human adipose tissue were injected into the tail vein of streptozotocin-induced diabetic rats. Finally, FNDC5 and irisin plasma levels of the mice were measured using enzyme-linked immunosorbent assay kits.
Results: FNDC5 and irisin levels reduced significantly in the diabetes control group (P=0.0001). FNDC5 levels in the diabetes + exercise + stem cell and the exercise group increased significantly compared to the diabetes control group (P=0.0001). The irisin level in the diabetes + stem cell + exercise group, exercise group and stem cell group increased significantly compared to the diabetes control group (P=0.0001).
Conclusion: The results indicate that aerobic exercise program and stem cell therapy alone and combined can significantly increase plasma irisin levels. Given the favorable effects of adipose tissue-derived stem cell injection and aerobic exercise on FNDC5 and irisin levels, this strategy could be further evaluated in coping with the adverse effects of diabetes on metabolism and aging
Mohammad Hossein Akha, Seyed Abdollah Hashemvarzi,
Volume 15, Issue 3 (May-Jun 2021)
Abstract
Background and objectives: The aim of this study was to compare the effect of an eight-weeks endurance and strength training on levels of cellular and vascular adhesion molecules in obese men.
Methods: Twenty-four obese volunteer men as subjects in this study were selected from Tehran and randomly assigned to control, endurance training, and strength training groups. The enduranBackground and objectives: Obesity, particularly abdominal obesity, is the most common cause of metabolic abnormalities, such as metabolic syndrome. The aim of this study was to compare effects of eight weeks of endurance and strength trainings on serum levels of cellular and vascular adhesion molecules in obese men.
Methods: Twenty-four obese men were randomly assigned to control, endurance training and strength training groups. The endurance training group performed a modified treadmill running protocol with an intensity of 50-70% of maximum heart rate. The resistance training included chest press, armpit stretch and leg and crus presses at intensity of 50-80% of one-repetition maximum. Serum levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion protein 1 (VCAM--1) were measured using commercial ELISA kits. Data were analyzed by one-way ANOVA and post hoc Tukey test at significance of 0.05.
Results: Serum VCAM-1 and ICAM-1 levels decreased significantly in both training groups compared to the control group (P=0.0001). The reduction of serum VCAM-1 and ICAM-1 levels was more significant in the endurance training group than in the resistance training group.
Conclusion: Given the favorable effects of endurance and resistance trainings on serum levels of VCAM-1 and ICAM-1, the eight-week training could be performed as a protective intervention in obese people.ce training group performed a modified running protocol with an exercise intensity of 50% to 70% of HRmax on the treadmill. Resistance exercises also included chest press, armpit stretch, and leg and crus presses. The training intensity was 50% to 80% of 1-RM. Serum levels of VCAM-1 and ICAM-1 were measured using ELISA commercial kits. Data were analyzed by One-way ANOVA and post hoc Tukey at the significant level P<0.05.
Results: VCAM-1 and ICAM-1 levels decreased significantly in training groups compared to the control (P = 0.0001). Significant differences were also found between the values of VCAM-1 and ICAM-1 in the endurance training group compared to the resistance training group (P = 0.0001).
Conclusion: Overall, the levels of molecules showed that the values of VCAM-1 and ICAM-1 decreased significantly in the exercise group compared to the control group, but this decrease was more significant in the endurance training group. Therefore, it seems that 8 weeks of training in obese people can be very useful and prevent many diseases.
Seyed Abdollah Hashemvarzi, Behrooz Mohammadnezhad,
Volume 19, Issue 3 (7-2025)
Abstract
Background and objectives: Inflammation plays a major role in the development and progression of diabetes. Vitamin D deficiency and physical inactivity can also increase the risk of developing type 2 diabetes. Combined therapeutic strategies are promising approaches for the treatment and prevention of diabetes. The aim of this study was to investigate effects of resistance training, vitamin D3 supplementation and adipose-derived mesenchymal stem cell (MSC) transplantation on tumor necrosis factor-beta level in the cerebral cortex of diabetic rats.
Methods: Eighty male Wistar rats (weighing 290±19 g) were randomly divided in to 10 groups: healthy control, sham, diabetes, training, vitamin D, MSC, training+vitamin D, MSC+training, MSC+vitamin D and training+MSC+vitamin D. Training groups were subjected to a resistance training program on ladder. MSC groups received 1.5 × 106 MSCs and vitamin D supplementation groups received 1 microgram/kilogram vitamin D3 eight times. Cortical TNF-β level and fasting serum glucose levels were measured.
Results: After 6 weeks, the combination of resistance training with vitamin D3 supplementation and MSC transplantation (P=0.018) as well as the combination of resistance training with MSCs (P=0.024) significantly reduced diabetes-induced elevation of TNF-β level.
Conclusion: Resistance training with appropriate intensity, duration and recovery between exercise sessions, combined with MSC transplantation and vitamin D3 supplementation has profound anti-inflammatory effects on the cerebral cortex tissue of diabetic rats. This type of intervention, especially the transplantation of MSCs, may be a promising protective strategy against some complications of diabetes.