Showing 5 results for Namjoo
Hr Joshaghani, Kh Kalavi, N Namjoo,
Volume 2, Issue 2 (Autumn – Winter 2009[PERSIAN] 2008)
Abstract
Abstract Background and Objectives: Erythrocyte indices are helpful for monitoring the erythrocyte synthesis and liver condition. The pesticide factories’ staff are being exposed to poisoning. This article aims to evaluate the effect of pesticides on blood indices of subjects which are exposed to organophosphate toxins. Material and Methods: This cohort study was conducted on the 63 employees of a pesticide factory In Gorgan.Iran (2005). We performed a two-step Sampling, The beginning of working season and three months later. Then, data analysis was carried out (p<0.05). Results: The difference between the mean of MCV in phase one (82.8 ± 7.1 fl) and phase two (80.3 ± 6.7) is Significant (p<0.001). The increase of Erythrocyte, hemoglobin, HCT, and MCHC in the second phase was statistically meaningful. There is not any significant relation between the work place, Record of Services and red blood cell indices. Conclusion: In regard to the changes in hematologic indices in a threemonth period, it seems logical to set up a program to have a routine check on the hematologic indices in people engaging in such occupations Key words: Pesticide, organophosphate toxins, hematologic indices, MCV, hemoglobin, hematocrit.
Koohsar F, Amini A, Ayatollahi A A, Noshak Gh, Hedayatmofidi H S, Namjoo M,
Volume 6, Issue 1 (spring-summer[PERSIAN] 2012)
Abstract
Abstract Background and objectives: Food handlers could be the main sources of intestinal parasite transmission in case of not observing the hygienic rules. Contamination can be decreased by screening food handlers through physical exam and laboratory tests. The aim of this study was determining the prevalence of intestinal parasites in 2010. Material and Methods: This cross-sectional research was carried out on 500 randomly selected individuals engaged in different food related careers. After filling out the questionnaire sheets, two specimens of feces were collected from each person and tested by brine 30% (floatation) and direct methods. Result: The results show that the prevalence of intestinal parasites is 6%. The highest prevalence is relateted to Giardia lamblia ( 17 4.3%) and the lowest to Hymenolepis nana ( 3 0.6%). in the age group of 60-51 years (11.8%) and individuals who just able to read and write (7.4%) The highest percentage is observed. The Most contamination is reported in butchery staff (25%) and the lowest in people worked in butler's pantry, without parasitic infections. Conclusion: The prevalence of intestinal parasitic infections are high relatively, especially pathogenic protozoan therefore, it is important be careful about health status of these individuals and their role in the spread of pollution. Key words: Intestinal Parasites, Food Handlers, Prevalence, Gorgan
Maryam Moradibinabaj , Mohadese Namjoo , Mojgan Nejabat , Hamidreza Joshaghani ,
Volume 10, Issue 1 (Jan,Feb 2016 2016)
Abstract
ABSTRACT
Background and Objective: The association of Triglyceride/High Density Lipoprotein-Cholesterol (TG/HDL-C) ratio with fasting serum insulin, which is an alternative method of insulin resistance (IR) measurement, is well-recognized. Thus, the measurement of TG/HDL-C ratio is useful to determine both IR and dyslipidemia, which itself is a characteristic of individuals with IR. Therefore, this study aimed to investigate the relationship between TG/HDL ratio as an indicator of IR, with different fasting blood glucose levels.
Methods: This case-control study was performed on 343 volunteers with no history of diabetes or use of blood glucose-lowering medications and fasting blood sugar (FBS) levels of less than 126 mg/dl. After sampling, the subjects were divided into three groups based on their FBS level. First group included healthy subjects with FBS of less than 100 mg/dl. Second group consisted of subjects with impaired fasting glucose (IFG) and FBS of 110-100 mg/dl and a third group including those with impaired glucose tolerance (IGT) and FBS of 110-125 mg/dl.
Results: The amount of TG/HDL-C ratio was 3.8 ± 2.8, 4.0 ± 2.1 and 5.4 ± 3.8 for the healthy group, individuals with IFG and IGT, respectively. The TG/HDL index was significantly different among the tested groups with no significant difference between healthy subjects and subjects with IFG. Moreover, there was a statistically significant difference between the IGT and IFG groups with healthy individuals.
Conclusion: Considering the significant increase of the TG/HDL ratio in groups with impaired glucose, using this index can be helpful in evaluation of glycemic disorder.
Mohadese Namjoo, Seyed Ali Taheri, Maryam Moradi, Mojgan Nejabat, Zahra Gari, Maryam Saboktakinrizi,
Volume 11, Issue 1 (Jan-Feb- 2017 2017)
Abstract
ABSTRACT
Background and Objectives: The unfavorable lipid profile in obese individuals is associated with high incidence of various diseases including cardiovascular disease, hypertension, etc. Dieting for weight loss and physical activity are among the most important factors affecting the serum lipid profile. The aim of this study was to compare the effect of diet with and without physical activity on body mass index and serum lipid profile of obese women.
Methods: This clinical trial was performed in 2011 on 39 obese women referred to a weight loss and nutrition counseling center. Subjects were randomly divided into an active group (diet and exercise) and inactive group (diet without exercise). Blood sampling was done before the intervention and two months after the intervention. Data was analyzed using SPSS-16 and t-test.
Results: Mean level of triglyceride reduced significantly in both groups. Mean level of cholesterol and low-density lipoprotein decreased significantly only in the active group. The Mean level of high-density lipoprotein in the two groups had no significant difference.
Conclusion: The results indicate that dieting for weight loss along with short-term physical activity improves serum levels of cholesterol and low-density lipoprotein, but does not affect serum HDL level.
Keywords: Diet, Exercise, Triglyceride, Cholesterol, LDL, HDL.
Mohadese Namjoo, Hossein Ghafoori, S. Mohsen Asghari,
Volume 17, Issue 1 (Jan-Feb 2023)
Abstract
Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosphorylation. The vascular endothelial growth factor receptor-2 (VEGFR-2) suppression could result in apoptosis induction. Therefore, targeting these pathways via VEGFR-2 inhibitors might have therapeutic potential for cancer treatment. It has been indicated that an antagonist peptide of VEGF, referred to as VGB3, could neutralize and recognize VEGFR2 in the tumoral and endothelial cells. This study aimed to induce apoptosis in human umbilical vein endothelial cells (HUVEC) cells through the inhibition of these signaling pathways.
Methods: Effects of different concentrations of VGB3 (1-200 ng/ml) were evaluated on the viability of HUVEC cells using MTT assay. In addition, downstream signaling pathways in HUVE cells were evaluated through quantitative assessment of protein expression via western blotting.
Results: The results demonstrated that VGB3 treatment inhibited the growth of HUVEC cells. Moreover, Bcl-2 was decreased in the cells treated with the VGB3 compared to the control. Furthermore, VGB3 significantly enhanced the cleaved-caspase7 levels, which is an indicator of apoptosis progression. Altogether, VGB3 enhanced apoptosis in HUVEC cells.
Conclusion: Our results indicate that the peptide might be a potential candidate for antitumor therapy via inhibiting the NF-κB pathway.
