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The Comparison Effect of Nanocopper Particles and Melissa Officinalis Essential Oil on Growth Inhibition of Escherichia Coli and Streptococcus Mutans
N Naghsh, Z Nikbakht, M Doudi,
Volume 7, Issue 5 (supplement Issue( Bacteriology)[PERSIAN] 2014)
Abstract
Abstract Background and Objective: the plants with the less side effects and drug resistance have been used worldwide. In this study, we compared the inhibitory effects of nanocopper and essential oil of Melissa officinalisL.a on E.coli and S.mutans in In Vitro condition. Material and Methods: for studying diameter of inhibitory zone, disk agar diffusion method was used. Then, antibacterial effects of these substances were evaluated by treating them for 24 hours in Nanocopper particles (concentration of 100 and 500 ppm) and essential oil (12.5% to 100%), and analyzed by ANOVA. Results: twenty-four hours after treatment, nanocopper had no inhibitory effect on these bacteria. However, the diameter of inhibitory zone for E.coli and S.mutans was 31.30±0.13mm and 16.30±0.13mm, respectively. There was not any synergistic effect between different concentrations of this plant and 500ppm of nanocopper after 24 hours of treatment on E.coli. But for S. Mutans, the diameter of inhibitory zone for mixture of 50% & 25% essential oil and 500ppm concentration of nanocupper was increased significantly compared to only essential oil (p=0.001,p=0.01). Conclusion: based on the findings, nanocopper particles and essential oil of Melissa officinalis L.a have not any synergic effects on E.coli, but with some concentrations of this plant the reverse is true on S.mutans. Keywords: Essential Oil of Melissa Officinalis, Nanocopper Particles, E.Coli, S.Mutans
Effect of Six Weeks of Swimming Training on Malondialdehyde and Superoxide Dismutase Levels in the Heart Tissue of Mice with Breast Cancer
Behnaz Vanaky, Nader Shakeri, Hojat Allah Nikbakht, Parvin Farzanegi,
Volume 12, Issue 3 (May-Jun 2018)
Abstract
ABSTRACT
         Background and Objectives: Breast cancer is one of the most common cancers among women. Cardiovascular disease is one of the most important complications of breast cancer. The aim of this study was to investigate the effects of six weeks of swimming on malondialdehyde (MDA) and superoxide dismutase (SOD) levels in the heart tissue of mice with breast cancer.
         Method: Breast cancer was induced in 30 female Balb/c mice (6-8 weeks old, weighing 150-200 g) by tumor transplantation. The tumor site was examined every day for the formation or absence of tumor. After becoming familiar with the laboratory environment and swimming pool, the subjects were randomly divided into three equal groups: 1. healthy control, 2. cancer control, and 3. swimming-cancer. The swimming group performed swimming training 60 minutes/day, five days a week, for six weeks. After the intervention, the levels of SOD and MDA in the heart tissue samples were evaluated by enzyme-linked immunosorbent assay. Data were analyzed in SPSS (version 16) using independent t-test at significance of 0.05.
         Results: The results showed that induction of breast cancer was accompanied by a significant increase in MDA and a significant decrease in SOD in the heart tissue of mice. Participation in the six-week swimming significantly reversed these effects.
         Conclusion: Swimming could have beneficial effects in improving oxidative factors in breast cancer patients.
         Keywords: Breast Neoplasms, Heart, Malondialdehyde, Superoxide Dismutase, Swimming.

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