Showing 4 results for Singh
Bhumika Gupta, Shivani Kalhan, Shalini Shukla, Shalini Bahadur, Gyanendra Singh, Rambha Pathak,
Volume 15, Issue 6 (Special issue (Nov-Dec) 2021)
Abstract
Introduction: COVID 19 pandemic caused by SARS-COV2 virus has taken a toll all over the world. The susceptibility of various diseases like Helicobacter Pylori, Hepatitis B virus and Norwalk Virus and even SARS Corona Virus 1 have been associated with ABO blood groups. However, very limited data is available regarding the COVID 19 susceptibility and ABO blood groups. Methods: In the present report we investigated 500 admitted patients who were RTPCR positive for corona virus. Significant Tests were applied to study association of blood groups vis a vis disease severity, ICU admissions and assisted ventilation. Results: We found out that Type A blood group is more susceptible to severe COVID 19 infection, even though maximum patients were of type B blood group. We also found that type A blood group needed more ICU admission and assisted ventilation then non type A groups and difference was statistically significant. Conclusion: Patients with type A blood group COVID 19 patients with type A blood group might require more vigilant surveillance and aggressive treatment measures. Further studies are required to validate the disease susceptibility.
Qudsiya Ansari , Anisha Jain, Kailas Randad, Vinaya Singh, Akash Sarkate,
Volume 18, Issue 5 (Sep-Oct 2024)
Abstract
Osteoporosis-pseudoglioma syndrome (OPPG) is a rare disorder characterized by severe osteoporosis and vision impairment, due to mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene. This autosomal recessive disorder is characterized by fractures, bone fragility, and pseudoglioma with blindness in infancy. Herein, we present a rare case of OPPG syndrome in an infant who, at 80 days of life (DOL), exhibited multiple fractures without any ophthalmic findings at the time of presentation. This is relatively earlier presentation of the symptoms as fractures are more commonly seen after two years of life.
Anuradha Saini , Anjali Sharma , Mukul Singh , Shaily Goyal , Maninder Narang , Sunil Ranga ,
Volume 19, Issue 3 (May-Jun 2025)
Abstract
Background: Sepsis stands as a leading cause of mortality among critically ill patients in intensive care units (ICUs). Bacterial infections, including sepsis, upregulate Neutrophilic cluster of differentiation 64 (nCD64) expression on activated polymorphonuclear leukocytes (PMNs). Prompt diagnosis of sepsis is crucial for initiating timely and targeted treatment. Consequently, a rapid laboratory test with high specificity for sepsis in adults would significantly aid therapeutic decision-making and help reduce the overuse of antibiotics.
Methods: This study enrolled 40 sepsis patients diagnosed according to the Sepsis-3 definition. For biomarker evaluation, 2 mL blood samples were collected from each patient in both ethylenediaminetetraacetic acid (EDTA) and plain vials. In addition, nCD64 was analyzed using flow cytometry, high-sensitivity C-reactive protein (hs-CRP) via nephelometry, and procalcitonin (PCT) using chemiluminescence.
Results: For sepsis prediction, nCD64 demonstrated a positive predictive value (PPV) of 92.68% and a negative predictive value (NPV) of 94.87%. A receiver operating characteristic (ROC) curve was generated to assess the diagnostic accuracy of nCD64 (≥ 1.8), hS-CRP (≥ 3 mg/L), and PCT (≥ 0.4 ng/mL). The area under the curve (AUC) for nCD64 was highest at 0.938 (95% confidence interval [CI] = 0.876-0.999), followed by hS-CRP at 0.888 (95% CI = 0.807-0.968) and PCT at 0.850 (95% CI = 0.759-0.941).
Conclusion: These findings strongly suggest that nCD64 determination is a valuable diagnostic tool for identifying infections in patients with septic syndrome. Its performance appears to be superior to that of hs-CRP and PCT.
Dr Roshita Devi Kshetrimayum, Dr Ajitkumar Singh Yanglem, Dr Sangeeta Naorem, Dr Victoria Kshetrimayum, Dr Sunie Laishram, Dr Niketa Ashem,
Volume 19, Issue 5 (9-2025)
Abstract
Background and objectives: Preeclampsia, a hypertensive disorder of pregnancy affects 10% of pregnancies causing both maternal and foetal complications. It may be associated with complications like visual disturbances, oliguria, eclampsia, hemolysis, elevated liver enzymes, thrombocytopenia, pulmonary edema and fetal growth restriction. Lactate dehydrogenase is an intracellular enzyme and is increased when there is increased cellular death. As preeclampsia leads to cellular death, serum LDH level may reflect the severity of preeclampsia and its level may serve as a guide in the management of the patient.
Methods: This is a cross sectional study, conducted in the Department of Biochemistry in collaboration with the Department of Obstetrics and Gynecology, RIMS, Imphal. The study population consist of 100 participants:50 diagnosed cases of preeclampsia and 50 non preeclamptic women attending RIMS hospital.
Results: The study shows that serum LDH level was significantly higher (p value < 0.05) in preeclamptic women (510.10±184.26)IU in comparison to the pregnant women without preeclampsia (284.38±97.35)IU. Serum LDH levels were found to be positively correlated with increase in blood pressure.
Conclusions: This study shows that serum LDH level is higher in patients with preeclampsia than the non preeclamptic women. LDH level is found to be positively correlated with higher blood pressure. Therefore, detection of serum LDH level may help in detection of preeclampsia so that it may help in close monitoring, prompt and early management of preeclamptic women.
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