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Changes in Some Hematology Parameters in poisoning with Rice Tablet (Aluminum Phosphide)
Farshid Fayyaz ,
Volume 9, Issue 4 (10-2015)
Abstract

Abstract

     Background and Objective: Aluminum Phosphide (ALP) is a solid non-organic phosphide with dark gray or dark yellow crystals. It reacts with stomach acid after ingestion and causes phosphine gas to be released. It is thought that phosphine causes toxicity from enzymatic interference and may even lead to cell death. This study aimed to investigate the effects of poisoning with rice tablet on levels of platelets, hemoglobin, white blood cells.

     Methods: The clinical records of 67 cases of acute oral toxicity with aluminum phosphide admitted to Baharloo hospital and 28 forensic autopsy cases in Kahrizak forensic research center were studied. Recorded information included vital signs, demographic characteristics, numerous laboratory and clinical findings, complications and all pathologic findings.

      Results: All patients had received standard symptomatic and supportive treatments. Among the tested subjects, 30 of 67 patients (44.8%) were male. The mean hemoglobin level of recovered and deceased individuals was 12.26 and 11.72 g/dl, respectively. There was a significant relationship between patients’ WBC counts and mortality where the mean level of WBC in the deceased  was more than that of the recovered (P=0.001). Mean SBP in the deceased and the recovered individuals was 79.67 ± 12.89 and 102.46 ± 22.57 mmHg, respectively.

      Conclusion: Consumption of rice tablets results in blood pressure alteration, hemoglobin levels, platelets and leukocyte count. Tracking these alterations can reduce the side effects and mortality rate in the cases of rice tablet poisoning.

     Keywords: Aluminum Phosphide, White Blood Cells, Hemoglobins, Blood Pressure, Patients


Effects of Four Weeks of High-Intensity Intermittent Training and Continuous Walking on Atherogenic Indices of Obese Middle-Aged Men
Minoo Dadban Shahamat, Asra Askari, Ramezan Arab Koohsar ,
Volume 15, Issue 2 (3-2021)
Abstract

Background and objectives: Elevated blood lipids and physical inactivity are known risk factors of atherosclerosis. The objective of this study was to compare effects of four weeks of high-intensity intermittent training (HIIT) and continuous walking on atherogenic indices of obese middle-aged men.
Methods: Study population consisted of 36 male teachers aged 35-50 years, with mean body mass index (BMI) of 30.7 ± 3.5 kg/m2 who were working in the city of Galikesh, northeastern Iran. The subjects were enrolled via purposeful sampling and were randomly divided into two experimental groups and a control group. Before and after the intervention, anthropometric characteristics (height, weight and BMI) and blood pressure of each subject were measured. Fasting blood samples were taken from the left brachial vein 12 hours before the first exercise session and 12 hours after the last exercise session to determine lipid profile. Data were analyzed using SPSS 18 at significance level of 0.05.
Results: The four-week walking exercise significantly decreased serum levels of low-density lipoprotein-cholesterol (LDL-C) (P=0.001) and triglyceride (P=0.001). In addition, the HIIT program significantly increased high-density lipoprotein level (HDL-C) (P=0.004) and significantly reduced LDL-C (P=0.049), LDL/HDL (P=0.002), triglyceride (p=0.01), BMI (P=0.027) and blood pressure (P=0.002). In addition, the results of ANOVA and (Scheffe test) showed a significant increase in HDL-C (P=0.042) values and a significant decrease in VLDL-C (P=0.032), LDL/HDL (P=0.041), triglyceride (P=0.024), BMI (P=0.048) and blood pressure (P=0.016) of HIIT group compared to the control group.
Conclusion: Our findings indicated that HIIT has beneficial effects on some risk factors of atherosclerosis and cardiovascular disease.


The Effect of Cigarette Smoking on Serum Homocysteine, Folic Acid, and Vitamin B12 Concentrations in Patients with Cardiovascular Diseases
Saif Karim, Mahdi Zahedi, Nahid Poursharifi, Mehdi Khorami, Mohsen Tatar,
Volume 19, Issue 1 (4-2025)
Abstract
Objective: The purpose of this study was to investigate the impact of smoking on blood homocysteine, folic acid, and vitamin B12 levels in patients with cardiovascular diseases (CVD). Methods: We collected 90 participants with cardiovascular complications who were divided into two groups:  Smokers (n=46) and non-smokers (n=44) groups. The serum levels of homocysteine, folic acid, and vitamin B12 were determined by the ELISA. Additionally, the systolic, diastolic blood pressure, and BMI were taken from patients. Results: Our results illustrated that the serum level of folic acid was significantly decreased in smoker patients (22.41±5.95) compared with the non-smokers group (28.05±4.13, p=0.000). In contrast, the serum level of homocysteine (p=0.958) and vitamin B12 (p=0.578) was not altered significantly between both groups. Our data also showed a negative correlation between folic acid and systolic blood pressure. No relationship was observed between folic acid and vitamin B12 and homocysteine in the smoking group. Conclusion: Our study showed that the levels of folic acid significantly decreased in CVD patients with smokers compared with non-smokers. A significant negative relationship was observed between folic acid and systolic blood pressure.
 
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