ABSTRACT
          Background and Objectives: Human chorionic gonadotropin (hCG) is the embryonic hormone and one of the most important factors for implantation. The present study aimed to evaluate effect of intra-uterine injection of hCG before embryo transfer on the pregnancy outcome in IVF.
         Methods: In this study, 180 infertile patients were randomly allocated into an experiment and a control group. In the experiment group, before embryo transfer, 500 IU hCG were injected into the endometrium cavity in puncture stage. Equal amount of phosphate buffer (placebo) was injected to the subjects in the control group. Pregnancy test was done two weeks after the intervention. In case of positive results, ultrasound scan was done for detecting the gestational sac and numbers of sacs. 
         Results: Mean age of the patients was 30±3.41 years and 31±4.12 years in the experimental and control group, respectively. There was no statistically significant difference in the duration of infertility between the two groups (4.77±3.67 years vs. 4.87±3.74 years). Based on the hCG level, the pregnancy rate was 35.5% in both groups. However, based on ultrasound findings, the pregnancy rate was 35.5% and 28.8% in the experiment group and the control group, respectively (P=0.33). In addition, there was no significant difference in the pregnancy rates between different age groups.
         Conclusion: Our results indicate that the intra-uterine injection of β-hCG has no significant effect on the pregnancy rate in IVF.   
        Keywords: Fertilization in Vitro, Chorionic Gonadotropin, Injections.

ABSTRACT
             Background and objectives: Accurate diagnosis of preterm rupture of membrane (PROM) is critical during pregnancy, and researchers are seeking ways to decrease the rate of false negative results in diagnostic tests. In the present study, we compare diagnostic properties of Amnisure test and human chorionic gonadotropin (hCG) test for diagnosis of PROM.
             Methods: The study was performed on singleton pregnant women (gestational age: 20 to 41 weeks) who were referred to the Taleghani Hospital in Tehran (Iran) between December 2016 and December 2017. The study included 44 PROM patients and 44 control pregnant women. Speculum examination for cervicovaginal fluid washing, hCG test and Amnisure test were performed for all of patients.  Statistical analysis of data was performed in SPSS software package (Version 18, Chicago, IL, USA) using t-test, Chi-square test, and Mann-Whitney test. P-values less than 0.05 were considered statistically significant.
             Results: The Amnisure test had better sensitivity and specificity compared with the β-hCG test (95.5% and 97.7% vs. 93.2% and 95.5%). The Amnisure test also had higher positive and negative predictive values than the β-hCG test (97.7% and 95.5% vs. 93.3% and 94.3%). Diagnostic accuracy of the Amnisure test was also higher than that of the β-hCG test (96.6% vs. 94.3%).
             Conclusion: According to the results, the two tests have almost equal diagnostic power for detection of PROM during pregnancy.
             Keywords: Chorionic Gonadotropin, Fetal Membranes, Premature Rupture