Showing 5 results for Heart
Farzad Nazem, Malihe Ardakani, Mohammad Reza Gholami, Kamal Ranjbar, Afshin Nazari,
Volume 10, Issue 5 (9-2016)
Abstract
ABSTRACT
Background and Objective: Scientific evidence reveals that the density of skeletal muscle microcirculations decreases in the patients with chronic heart failure. Therefore, this study aimed to determine the impact of submaximal aerobic exercise training on restoration of fast/slow-twitch muscle fibers microcirculation in rats with myocardial infarction.
Methods: In this experimental study, 30 male infarcted Wistar rats were randomly divided into three groups of sham (N=10), control (N=10) and exercise (N=10), four weeks after surgery (blockage of anterior descending artery). Daily aerobic exercise included running on a treadmill for 10 weeks (5 times a week) at a speed of 17 m/min within 10 to 50 minutes. The animals were anesthetized and then sacrificed with chloroform, 48 hours after the last training session. The microcirculation density of soleus (SOL) and gastrocnemius (Gw) muscles was evaluated by immunohistochemistry assay.
Results: Capillary density and capillary to SOL muscle fiber ratio significantly increased in response to exercise training. However, capillary density, capillary to Gw muscle fiber ratio and Gw muscle arteriolar density of Wistar rats with chronic heart failure were not significantly affected by the exercise program. Moreover, arteriolar density of Gw muscle increased significantly after the exercise program.
Conclusion: The ten-week aerobic exercise might non-uniformly improve the SOL and Gw muscles microcirculation in rats with chronic heart failure by increasing capillary density and capillary to fiber ratio in the SOL muscle and increasing the arteriolar density of the Gw muscle.
Keywords: Heart Failure, Angiogenesis, Exercise.
Behnaz Vanaky, Nader Shakeri, Hojat Allah Nikbakht, Parvin Farzanegi,
Volume 12, Issue 3 (5-2018)
Abstract
ABSTRACT
Background and Objectives: Breast cancer is one of the most common cancers among women. Cardiovascular disease is one of the most important complications of breast cancer. The aim of this study was to investigate the effects of six weeks of swimming on malondialdehyde (MDA) and superoxide dismutase (SOD) levels in the heart tissue of mice with breast cancer.
Method: Breast cancer was induced in 30 female Balb/c mice (6-8 weeks old, weighing 150-200 g) by tumor transplantation. The tumor site was examined every day for the formation or absence of tumor. After becoming familiar with the laboratory environment and swimming pool, the subjects were randomly divided into three equal groups: 1. healthy control, 2. cancer control, and 3. swimming-cancer. The swimming group performed swimming training 60 minutes/day, five days a week, for six weeks. After the intervention, the levels of SOD and MDA in the heart tissue samples were evaluated by enzyme-linked immunosorbent assay. Data were analyzed in SPSS (version 16) using independent t-test at significance of 0.05
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Results: The results showed that induction of breast cancer was accompanied by a significant increase in MDA and a significant decrease in SOD in the heart tissue of mice. Participation in the six-week swimming significantly reversed these effects
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Conclusion: Swimming could have beneficial effects in improving oxidative factors in breast cancer patients.
Keywords:
Breast Neoplasms, Heart, Malondialdehyde, Superoxide Dismutase, Swimming.
Nasrin Ramezani , Behnaz Vanaky , Nader Shakeri , Zahra Soltanian , Fatemeh Fakhari Rad , Zahra Shams ,
Volume 13, Issue 1 (1-2019)
Abstract
ABSTRACT
Background and Objectives: Diabetes is one of the most common diseases and a major risk factor for cardiovascular disease. Studies have shown that regular exercise can affect apoptosis in cardiomyocytes. The purpose of this study was to investigate the effect of high-intensity interval training on the expression of Bcl-2 and Bax as important apoptosis factors in diabetic rats.
Methods: After inducing diabetes in 20 male Wistar rats (weighing 250 ± 1.15 g), the rats were randomly divided into a control group and a training group. The training group performed high-intensity interval training five days a week for four weeks, and the control group did not perform any training. After the intervention, RNA was extracted and TCF mRNA was subjected to real time RT-PCR for measuring Bax and Bcl-2 expression in the heart tissue of diabetic rats. Data were analyzed by IBM SPSS Statistics V22 using independent t-test. P-values less than 0.05 were considered as statistically significant.
Results: The expression of Bcl-2 increased significantly and the expression of Bax decreased significantly after the four-week training intervention.
Conclusion: The high-intensity interval training can have beneficial effects on the expression of apoptotic genes in rats with type 2 diabetes.
Keywords: Bax, Bcl-2, High intensity interval training, Heart, Type 2 diabetes.
Seyed Mahmud Hejazi, Ladan Hosseni Abrishami,
Volume 14, Issue 5 (9-2020)
Abstract
Background and objectives: Evidence has shown that inflammatory mediators play an important role in the pathogenesis of atherosclerosis. The aim of this study was to evaluate effects of eight weeks of continuous and intermittent aerobic exercise on some inflammatory indices in men with heart failure.
Methods: The effects of continuous aerobic exercise (at 45-70% maximum heart rate) and intermittent aerobic exercise (at 45-80% of maximum heart rate) on the level of interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor alpha (TNFα) were evaluated in 42 men with heart failure using commercial ELISA kits. Blood samples were taken after 12 hours of fasting one hour before the first session and 48 hours after the last exercise session. The subjects performed exercises three sessions a week, for eight weeks. Data were analyzed by one-way ANOVA at significance of 0.05.
Results: After the exercise program, serum hs-CRP (P=0.023), IL-6 (P=0.018) and TNF-α (P=0.048) differed significantly between the exercise groups and the control group. In addition, serum levels of IL-6 and hs-CRP decreased slightly in the intermittent aerobic group, but there was no significant difference between the two exercise groups. Intermittent aerobic exercise significantly reduced serum TNF-α level compared to the control group.
Conclusion: Probably aerobic exercise can have positive effects on the level of hs-CRP, IL-6 and TNF-α in patients with heart failure.
Shiva Bahram Vash Shams, Parvin Farzanegi, Mohammad Ali Azarbayjany,
Volume 15, Issue 3 (5-2021)
Abstract
Background and objectives: Oxidative stress is the most important pathophysiological cause of diseases. Studies have shown that exercise and supplementation with medicinal plants have limited side effects. The aim of the present study was to evaluate effects of aerobic exercise and ethanolic extract of purslane seed on ATP, O-6-Methylguanine DNA methyltransferase (MGMT), malondialdehyde (MDA) and prooxidant-antioxidant balance (PAB) levels in the heart tissue of rats poisoned with hydrogen peroxide.
Methods: In this experimental trial, 72 male Wistar rats were randomly divided into nine groups: (1) control + H2O2 , (2) aerobic exercise, (3) aerobic exercise and 50 mg/kg purslane seed extract, (4) aerobic exercise and 200 mg/kg purslane seed extract, (5) aerobic exercise and 400 mg/kg purslane seed extract, (6) 50 mg/kg purslane seed extract, (7) 200 mg/kg purslane seed extract, (8) 400 mg/kg purslane seed extract, and (9) healthy control. Oxidative stress was induced by intraperitoneal injection of 1 mmol/kg hydrogen peroxide three times a week for eight weeks. Aerobic exercise was performed three sessions a week for eight weeks, and the purslane seed extract was intraperitoneally injected daily at the mentioned doses.
Results: Aerobic exercise and purslane seed extract alone or combined significantly increased ATP, MGMT and significantly reduced MDA and PAB levels in cardiac tissue of rats exposed to hydrogen peroxide (P<0.05). Moreover, the effect of purslane seed extract was dose dependent.
Conclusion: It seems that aerobic exercise and purslane seed extract supplementation have synergistic cardioprotective effects under oxidative stress.
