Seyedeyn Khorasani, M, Yousefi Mashouf, R, Majlesi, A, Jaefari, M, Alikhani, My,
Volume 9, Issue 1 (4-2015)
Abstract
Abstract
Background and Objective: Helicobacter pylori (H. Pylori) infection is related to chronic gastritis, peptic ulcer, duodenal ulcer and gastric cancer. Thus, identification and treatment of the infection have a considerable importance. The aim of this study was to compare three methods of Histopathology, Culture and Rapid Urease test (RUT) in identification of H. Pylori in gastric biopsy specimens.
Material and Methods: The participants were 153 patients (64 women and 89 men) suffering from digestive complaints, who referred to the endoscopy department of Shahid Beheshi Hospital in Hamadan, Iran. Three gastric biopsy samples were collected from each patient and examined by standard RUT, Histopathology and culture methods for diagnosis of H. Pylori.
Results: Out of 153 patients, 69.9%, 27.4% and 2.6 % had gastritis, gastric ulcer and gastric cancer, respectively. The rate of infection with Urease test, culture and histology were identified 49.7%, 54.2%, and 89.5%, respectively. The sensitivity and specificity of the RUT result at first hour and after the first up to 24 hours were 55.4% and 80%, and 55.4% and 66/7%, respectively. The sensitivity and specificity of culture method were 60.6% and 100%, respectively.
Conclusion: Based on the results, Histopathology method has a more sensitivity than both Culture method and rapid urease test for diagnosis of H. Pylori, and RUT is more specific when done in the first hour rather than after the first hour.
Key words: Helicobacter pylori, rapid urease test methods, RUT, Histopathology
Dr Dipankar Thakuria, Dr Karan Kumar Borah, Dr Projnan Saikia, Dr Kusum Borsaikia,
Volume 19, Issue 3 (7-2025)
Abstract
Background: Pathological autopsy plays a crucial role in understanding mortality causes, especially in cases where diagnosis during life was incomplete or impossible. The collaboration between forensic experts and pathologists provides valuable insights into the cause and manner of death. Aim: The study aimed to determine the prevalence and pattern of lung, liver, and kidney histopathology, assess demographic associations, and investigate etiological factors contributing to these pathologies. Methods: A retrospective, non-interventional, record based cross sectional study was conducted for a period of five years from 1st January 2019 to 31st December 2023, analyzing 90 autopsy cases excluding decomposed bodies and cases primarily due to extensive trauma. Results: Lung pathology was observed in 61.1% of cases, predominantly showing congestion and inflammation. Liver diseases were found in 47.7% of cases, with steatosis and cirrhosis notable, especially among males. Kidney pathology was present in 50% of cases, with various changes noted. Demographic distribution indicated a higher prevalence among males, with sudden death, chronic alcohol abuse, and road traffic accidents being common causes. Conclusion: The study emphasizes the significant burden of lung, liver, and kidney pathology in autopsy cases, particularly among males, highlighting the importance of autopsy in understanding the underlying causes of death and guiding public health interventions and forensic investigations.
