Showing 5 results for Neonatal
A Maleki, Sh Ebrahimian,, M Omranii, A Ranjbar, A Mikaeili,
Volume 3, Issue 1 (4-2009)
Abstract
Abstract Background and objectives: Blood culture is a critical part of evaluation of Neonate suspected wath Septicaemia. This phenomenon is one of the most important causes of neonates in Neonatal. Material and Methods: This study was carried out on 1470 somples of neonates suspected with bacteraemia , using reutine microbiologicul technique. The samples wene assessed in hazrate Masoomeh hospilal of Kermansha,Iran. Results and Conclusions: of all samples, 112 (7.62%) ane pasitive. Most of the Positive cultures were obtained after 24 hours of incubation in broth mediu. we Confirmed this result by using diseriminafiue culture media the Isolated bacteria are Coagulase-negative Staphylococus(28.6%),Alfahymolylic Streptococus(0.09%), staphylococus aureus(10.7%),Klebseilla(6.2%),pseudomonas(12.5%),moraxella(0.9%),acin eto bacter(13.4%), Alcalingenes(13.4%),protenos(1.8%) and salmonela (0.9%). Conclusion: the frequency of Coagulase-negative Staphylococus Isolated from neonates Blood culture is more than the other micro organisms. Generally, the frequency of gram negative bacteria is higher than gram Positive. Key words: Septicaemia, Blood culture, Bacteraemia, Neonatal
Nazari, H, Habibeh Najar, H, Emadi, A, Abasi, Y, Salehiyan, A, Monem, M, Ghods, F, Mohammadi, A., Khaleghian, A,
Volume 5, Issue 2 (10-2011)
Abstract
Abstract Background and objectives: Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway. G6PD deficiency (an X-linked recessive hereditary disease) is an inherited condition affecting approximately 3% of the people globally. This deficiency can cause hemolytic anemia and jaundice in neonates. The goal of this study is to detect the prevalence of G6PD deficiency in neonates referred to Semnan province screening lab Material and Methods: This cross sectional study, from 2007 to 2010, was conducted on the basis of country planned program and in line with neonatal screening tests. Blood samples were taken from the heels of 3-5 day neonates. Assessment of G6PD was done by rapid fluorescent spot test. The Prevalence of G6PD deficiency in boys and girls was compared by chi square (p<0.05(test. Results: Of 9353 newborns referred to semnan province screening Lab., 4820(51.53%) are males and 4533(48.47%) females. Three hundred (3.2%) of them suffer from G6PD deficiency. Of these, 263 (5.45%) are males and 37 (0.81%) females. The ratio of male to female is 7 to 1. Conclusion: The prevalence of G6PD deficiency is detected 3.2% in Semnan province and its frequency in boys is more than that of girls, which is expected. Key words: Glucose -6-phosphate dehydrogenase, Neonatal screening, Fauvism
Mm Soltan Dallal, Z Rajabi,
Volume 9, Issue 3 (9-2015)
Abstract
Abstract
Background and Objective: This study aimed to investigate the antimicrobial susceptibility of the most common pathogens in hospitalized neonates in Intensive Care Unit.
Material and Methods: In this one-year descriptive study, 150 blood samples of neonates in Intensive Care Unit of Bahrami hospital of Tehran were divided into two groups of early onset sepsis (the first 72 hours of life) and late onset sepsis (after the 72 hours of life). After isolating and identifying of bacteria, their antibiotics susceptibility was studied by Kirby- bauer method in accordance with CLSI guidelines.
Result: The most isolated organisms were Klebsiella pneumoniae (41.3%). Coagulase negative staphylococcus was the cause of early onset septicemia and Klebsiella pneumoniae of both early and late onset septicemia. The highest susceptibility in gram-negative microorganisms was shown to Ciprofloxacin (89.6%) and in gram positive to Vancomycin (82.8%).
Conclusion: Gram-negative bacteria are the main cause of contamination in NICU and ciprofloxacin is the most effective antibiotic. Thus, it is imperative that NICU should be extremely controlled.
Keywords: Septicemia; Antibiotic Susceptibility; Neonatal Intensive Care Unit
Neema Tiwari , Richa Sharma , Prachi Saxena ,
Volume 19, Issue 4 (7-2025)
Abstract
Background: Nucleated red blood cells (nRBCs) are immature erythrocytes whose production is thought to be driven primarily by the interplay of hypoxia and erythropoietin synthesis. Neonatal sepsis is classified as early-onset (occurring within the first 24 hours of life) or late-onset (Occurring after 48-72 hours). The aim of this study was to analyze the cause for the presence of nRBCs in the peripheral blood of neonates sent for routine workup in the Hematology Laboratory of the Department of Pathology, SMSR, Sharda University.
Methods: Retrospective analysis of 27 complete blood counts and peripheral blood smears of neonates was conducted over one month. Smears had been prepared and stored for examination, and reports had been dispatched. Clinical details (As available from clinicians), parameters for neonatal sepsis (NLR, PLR, IG), platelet counts, and nRBC counts were recorded and tabulated. For result tabulation, neonatal samples were divided into two groups: 0-1 day and 2-30 days.
Results: The neonates included 17 males and 9 females. Assessment of NLR, PLR, and IG indicated higher values in the 2-30-day group compared to the 0-1-day group. Moreover, nRBCs were also elevated in the 2-30-day group.
Conclusion: The presence of nRBCs in peripheral blood smears is an important indicator of neonatal stress, including sepsis, jaundice, and hypoxic sepsis.
Karvi Agarwal , Amit Garg, Konpal Agarwal , Naila Begum ,
Volume 20, Issue 2 (3-2026)
Abstract
Background: Burkholderia gladioli (B. gladioli) is a rare but emerging pathogen associated with neonatal sepsis. This case series describes the investigation and control of an outbreak in a tertiary neonatal intensive care unit (NICU) in India.
Methods: In January 2024, seven neonates admitted to the NICU developed bloodstream infections. Clinical manifestations included respiratory distress, feeding refusal, metabolic acidosis, seizures, and shock. Predisposing factors included prematurity, congenital anomalies, and perinatal asphyxia. Blood cultures were processed using the automated BD BactecFX-40 system, and organism identification with antimicrobial susceptibility testing was performed using the BD Phoenix M-50 system. Environmental sampling was conducted to identify the outbreak source.
Results: Of 72 blood culture bottles, 34 (47.2%) flagged positive. B. gladioli were isolated from seven patients, accounting for 20.6% of positive cultures. The overall mortality rate was 57.1% (4/7 Deaths). All clinical isolates showed identical susceptibility patterns, with susceptibility to levofloxacin, cotrimoxazole, ceftazidime, chloramphenicol, minocycline, and meropenem, and intrinsic resistance to colistin. Environmental surveillance identified the same B. gladioli strain from suction apparatus and phototherapy units. Contributory factors included poor hand hygiene compliance (28-33%), limited glove availability, and overcrowding. Following cohorting, deep cleaning with 1% hypochlorite, staff retraining, and reinforcement of infection control protocols, no further isolates were recovered.
Conclusion: This outbreak highlights the high mortality associated with B. gladioli sepsis in neonates and underscores the critical need for stringent infection control practices and automated identification systems in NICUs. To our knowledge, this is the first such report from India.
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