Showing 8 results for Pregnancy
Sh Aram, A Khalilian,
Volume 1, Issue 1 (4-2007)
Abstract
Abstract Background and objectives: Despite prenatal care, pre-eclampsia is still one of the most important causes of maternal and fetal mortality. There is no screening test for pre-eclampsia to be reliable and economical. One of the most accessible and easiest screening tests is blood uric acid measurement. The goal of this study is to assess the level of uric acid in high risk pregnant women a few weeks before emerging the manifestations of pre- eclampsia. Materials& Methods: In this study carried out in Isfahan medical centers, 124 pregnant women with gestational age of 24-28 weeks were selected by simple non-probability sampling. Then the subjects' uric acid were measured and considered high if it would be more than 4.5mg/dl. Results: of all the subjects, only 20 (16.1%) suffered from preeclampsia. 10 of 39(31.4%) who had high uric acid(more than 4.5mg/dl) showed pre-eclampsia.It is true for low uric acid women(68.6%), that is , the number of pre-eclampsia was ten. Conclusion: Relative risk of increased level of uric acid in preeclampsia at 24-28 weeks of gestational age was 2.2. Chi-square test showed that there is significant difference between the level of uric acid at 24-28 weeks of gestational age and the Incidence of preeclampsia. Keywords: pre-eclampsia, uric acid- high risk pregnancy
M Saeedi, S Bakhshandeh Nosrat, A Moradi, Sm Hedayat Mofidi, N Behnampoor,
Volume 3, Issue 1 (4-2009)
Abstract
Abstract Background and objectives: Infection has a Leading role in pregnancy. Cytomegalovirus (CMV), listeria and Toxoplasma are the most common causes of infection in human. Based on the previous researches, about 15-25 percent of being infected during pregnancy leads to some complications such as abortion, fetal death, early labor and etc. This study was designed to determine the seroprevalence of Cytomegalovirus (CMV), Toxoplasma gondii and Listeria moncytogenes among pregnant women in Gorgan, north of Iran (2005-2006). Material and Methods: we conducted this Simple randomized study on 118 unsuccessful pregnant woman and 99 successful ones referred to Deziani hospital in Gorgan. We assayed both IgG and IgM antibodies for CMV and Toxo by Elisa and IFA method for Listeria. In addition, we fill out a Check list and then use SPSS soft ware, chi square to analyze the data. Results: The frequency of IgG for CMV and Toxo is 89.9% and 45.5% in successful pregnant women and 77.1% and 44.1% for unsuccessful pregnant women (P=0.41, P=0.01). IgM frequency for CMV and Toxo is 14.1% and 46.5% in successful women and 30.5 and 21.7% in unsuccessful ones. (P=0.003, P=0.002)Total frequency (IgG, IgM) for Listeria is 7.62% and %3.03 in successful and unsuccessful women, respectively. There is a significant relation between abortion and IgM titer against Toxoplasma in successful and unsuccessful groups. (P=0.003).This relation is true for total antibody titer against Listeria (P=0.003). Conclusion: Because of high titer of antibodies against CMV, Toxo and Listeria in unsuccessful pregnant women, suffering from these agents during pregnancy may result in abortion and fetal death. Hence, we recommend to hold some preventive and educational program and also to assay antibodies against theses agents. Key words: Listeria moncytogenes, Cytomegalovirus (CMV), Toxoplasma gondii, success and non-success pregnancy, Serology, Gorgan
A Ebrahimzadeh, S Mohammadi, T Davoodi, Ar Salimi Khorashad, A Jamshidi,
Volume 7, Issue 3 (10-2013)
Abstract
Abstract
Background and Objective: Toxoplasmosis is one of the most prevalent parasitic infections worldwide. Contamination of pregnant women with toxoplasmosis may cause fetal death, preterm delivery and congenital toxoplasmosis. Due to importance of congenital Toxoplasmosis and the need of further study, this research was accomplished in Zahedan.
Material and Methods: The serum samples (N= 221) were collected from pregnant women referring to reference laboratory of Zahedan in 2011. The IgG and IgM antibody levels against toxoplasmosis were investigated using ELISA method.
Results: Out of all samples, 30.8% are IgG positive and 1.4% are both IgG and IgM positive. There is no significant difference between positive and negative groups using Chi-square tests.
Conclusion: The main part of pregnant women in Zahedan (69.2%) is serologically negative against toxoplasmosis therefore, hygiene education to eliminate risk factors especially during pregnancy period seems to be imperative.
Keywords: ELISA Antibody Pregnancy Toxoplasma Zahedan
Negin Rezavand, Asad Vaisi-Raygani, Firozeh Vaisi, Maryam Zangneh , Azin Hoshiar , Fariborz Bahrehmand, Amir Kiani, Gholamabass Dinarvand ,
Volume 10, Issue 4 (7-2016)
Abstract
ABSTRACT
Background and Objective: Nutritional factors and activation of inflammatory pathways are thought to be involved in pathogenesis of preeclampsia in pregnant women. The present study aimed to compare the serum levels of vitamin D and interleukin-6 in healthy pregnant women with those of preeclampsia ones.
Methods: This case-control study was performed on 120 healthy pregnant women and 120 women with preeclampsia referred to Imam Reza Hospital in Kermanshah. The serum levels of vitamin D and IL-6 were measured by ELISA method. The data was analyzed by SPSS software (version 20) using independent t-test, the P-value of <0.05 was considered as statistically significant.
Results: There was no statistically significant difference between the mean level of vitamin D in the patients (37.64 ± 29.50 ng/ml) and the controls (40.06 ± 33.20 ng/ml). the serum level of IL-6 in patients with preeclampsia (21.71 ± 32.24 pg/ml) was significantly higher compared to that of control group (15.04 ± 28.6 pg/ml) (P <0.001).
Conclusion: Based on the findings of this study, inflammatory factors and cytokines such as IL-6 can be considered as risk factor for preeclampsia. However, more studies with larger sample sizes are required to further evaluate the association of vitamin D levels and risk of preeclampsia.
Keywords: Pregnancy, Pre-Eclampsia, Vitamin D, Interleukin-6.
Zeinab Nazari, Javad Ghaffari, Negar Ghaffari,
Volume 14, Issue 3 (5-2020)
Abstract
Background and Objectives: Human T lymphotropic virus type I (HTLV-I) is a virus of the Retroviridae family, which has infected more than 20 million people around the world. The study aimed to review the prevalence of HTLV infection in pregnant women.
Methods: We searched various databases including PubMed, EMBASE, Scopus, Google Scholar, SID, Magiran and Irandoc using the following keywords: HTLV-1, HTLV-2, Retroviridae, pregnancy, prevalence, incidence, women and female. Abstracts, short/brief reports as well as original and review articles published on HTLV-1 and/or HTLV-2 infection during pregnancy until October 2018 were included in the study.
Results: We found five articles from Iran and 14 articles from other parts of the world on the prevalence of HTLV-1 infection in pregnant women. Prevalence of HTLV-1 and or HTLV-2 was higher in pregnant women than in non-pregnant women in cities of Mashhad and Neyshabur, Razavi Khorasan Province (1.5 to 3.3 %), northeastern Iran, which are endemic areas of Iran for HTLV-1 infection. The incidence rate of HTLV-1 infection was 400-500 per 10,000 pregnant women in endemic areas of Japan. In Brazil, the rate of HTLV-1 infection in pregnant women was estimated to be 1.05%.
Conclusion: The prevalence of HTLV-1 varies among pregnant women depending on residence in endemic or non-endemic areas for HTLV-1. In endemic areas, it is recommended to perform routine screening for HTLV-1 infection in the general population, especially pregnant women.
Akhtar Seifi, Negarsadat Taheri, Hanieh Kia, Hady Reza Mansourian, Azad Reza Mansourian,
Volume 16, Issue 4 (7-2022)
Abstract
The prevalence of hypothyroidism is much higher among women than in men. Hypothyroidism is also one of the most prevalent thyroid disorders among women of reproductive age. The disease exerts its effect on female sex hormones by manipulating the production of luteinizing hormone and follicle-stimulating hormone that are crucial for the production of estrogen by the ovaries. Various studies demonstrated the adverse effect of overt hypothyroidism on ovulation, menstrual cycle, and fertility. This review surveys the adverse effects of hypothyroidism on fertility and pregnancy.
Shadmehr Mirdar, Monireh Khalili , Neda Aghaei Bahmanbeglou ,
Volume 17, Issue 5 (9-2023)
Abstract
Background: Exercise and dietary supplements can partially mitigate the negative effects of cadmium. The present study aimed to investigate the effect of swimming and silymarin on placental growth factor (PLGF) in pregnant mice exposed to cadmium.
Methods: Seventy-two 8-week-old pregnant Wistar rats (weighing 20 ± 200 g) were divided into 9 groups, with 8 rats in each group. Cadmium chloride at a dose of 400 mg/kg body weight was fed to rats by drinking a water solution. Silymarin (100 mg/kg body weight) was injected subcutaneously 3 times a week. The exercise program during pregnancy consisted of 60 minutes of swimming per day, conducted for 5 days a week. The microscopic sections of samples were taken 2 days after birth using the usual method of tissue sectioning. A 1-way analysis of variance (ANOVA) and Tukey post hoc test at the error level of 0.05 were used to analyze the data.
Results: The PLGF index in the cadmium group showed a significant decrease (P < 0.001) compared to the cadmium + silymarin and cadmium + silymarin and swimming groups. However, swimming training alone had no effect on PLGF index (P = 0.162).
Conclusion: Cadmium significantly reduced PLGF levels in neonatal lung tissue, and regular swimming endurance exercises and silymarin supplementation inhibited the effects of cadmium chloride.
Thivyah Prabha, Rasheed Khan, Shruthi Cn, Rathi Priya,
Volume 17, Issue 6 (11-2023)
Abstract
Background: Thyroid disorders are the most common cause of endocrine dysfunction among women of childbearing age. It is well-established that hypothyroid dysfunction can have significant adverse effects on pregnancy and fetal development. This study aimed to determine the prevalence of thyroid disorders among antenatal women and assess the maternal and fetal outcomes in pregnant women with hypothyroid disorders.
Methods: This prospective study was conducted in the antenatal clinic of the Department of Obstetrics and Gynaecology in association with the Biochemistry Department. After obtaining written informed consent, antenatal women aged 18-40 years were included in this study, regardless of their gestational period. Venous blood samples were collected from the antecubital vein, and thyrotropin, free triiodothyronine (free T3), and free thyroxine (free T4) levels were measured. Hypothyroid antenatal women were monitored throughout their pregnancies to evaluate maternal and fetal outcomes.
Results: Among the participants in this study, 149 antenatal women had thyroid disorders, with a prevalence rate of 12.6%. Subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism were observed in 6.9%, 3.2%, 1.8%, and 0.7% of cases, respectively. Maternal complications included oligohydramnios (5.8%), preeclampsia (13.3%), and preterm delivery (5%), while fetal complications included low birth weight (20.8%), hyperbilirubinemia (9.1%), and neonatal intensive care unit (NICU) admissions (13.3%).
Conclusion: A high prevalence (12.6%) of thyroid disorders, particularly hypothyroidism (10.1%), among pregnant women, emphasizing the importance of routine thyroid testing for all antenatal individuals.
