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mljgoums 2023, 17(1): 20-26 |
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Nikkar H, Rshidlamir A, Khajei R, Barjaste A, Vazifedoost M. Effects of 8 Weeks of Combined Rehabilitation Training on Plasma Levels of Leptin, Adiponectin, and Resistin in Middle-Aged Men after CABG. mljgoums 2023; 17 (1) :20-26
URL: http://mlj.goums.ac.ir/article-1-1395-en.html
URL: http://mlj.goums.ac.ir/article-1-1395-en.html
1- Department of Exercise Physiology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
2- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad , Mashhad, Iran.
3- Department of Exercise Physiology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran ,r.khajeie@gmail.com
4- Department of Food Science and Technology, Neyshabur branch, Islamic Azad University, Neyshabur, Iran
2- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad , Mashhad, Iran.
3- Department of Exercise Physiology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran ,
4- Department of Food Science and Technology, Neyshabur branch, Islamic Azad University, Neyshabur, Iran
Abstract: (1780 Views)
Background and objectives: Coronary artery bypass graft (CABG) is a surgical procedure used to treat coronary heart disease. The present study aimed to investigate effects of 8 weeks of combined rehabilitation training on plasma levels of leptin, adiponectin, and resistin in middle-aged men who have undergone CABG.
Methods: The present research was a quasi-experimental study with a pretest-posttest design. The statistical population included all patients who have undergone CABG in Mashhad, Iran. Overall, 26 middle-aged men who have undergone CABG were enrolled in the study. The subjects were divided into a training group (n=14) and a control group (n=12). Data were analyzed in SPSS software (version 21) using analysis of covariance and paired t-test at significance level of 0.05.
Results: Plasma levels of leptin did not change significantly (p=0.709), adiponectin increased significantly (p=0.001), and resistin decreased significantly (p=0.005) after the training intervention.
Conclusion: As a non-pharmacological intervention, the rehabilitation training has cardioprotective effects on patients who undergone CABG.
Methods: The present research was a quasi-experimental study with a pretest-posttest design. The statistical population included all patients who have undergone CABG in Mashhad, Iran. Overall, 26 middle-aged men who have undergone CABG were enrolled in the study. The subjects were divided into a training group (n=14) and a control group (n=12). Data were analyzed in SPSS software (version 21) using analysis of covariance and paired t-test at significance level of 0.05.
Results: Plasma levels of leptin did not change significantly (p=0.709), adiponectin increased significantly (p=0.001), and resistin decreased significantly (p=0.005) after the training intervention.
Conclusion: As a non-pharmacological intervention, the rehabilitation training has cardioprotective effects on patients who undergone CABG.
Research Article: Original Paper |
Subject:
Sport Physiology
Received: 2021/06/23 | Accepted: 2022/06/6 | Published: 2023/01/20 | ePublished: 2023/01/20
Received: 2021/06/23 | Accepted: 2022/06/6 | Published: 2023/01/20 | ePublished: 2023/01/20
References
1. Bomma K, Murmu NN, Rao A. A Study of the Conventional Risk Factors and Early Outcomes of Coronary Artery Bypass Grafting in Patient with Early Onset of Coronary Artery Disease (Age< 45 Years): A Five Year Retrospective Study. [Google Scholar]
2. Fazlzadeh M, Rostami R, Yousefian F, Yunesian M, Janjani H. Long term exposure to ambient air particulate matter and mortality effects in Megacity of Tehran, Iran: 2012-2017. Particuology. 2021;58:139-46. [View at Publisher] [DOI:10.1016/j.partic.2021.01.017] [Google Scholar]
3. MacKay EJ, Zhang B, Heng S, Ye T, Neuman MD, Augoustides JG, Feinman JW, et al. Association between Transesophageal Echocardiography and Clinical Outcomes after Coronary Artery Bypass Graft Surgery. J Am Soc Echocardiogr. 2021 ;34(6):571-581. [View at Publisher] [DOI:10.1016/j.echo.2021.01.014] [PubMed] [Google Scholar]
4. Irving A, Harvey J. Regulation of hippocampal synaptic function by the metabolic hormone leptin: Implications for health and disease. Prog Lipid Res. 2021 ;82:101098. [View at Publisher] [DOI:10.1016/j.plipres.2021.101098] [PubMed] [Google Scholar]
5. Parameshwar A, Maiya GA, Kamath SU, Shastry BA, Ravishankar. Lifestyle Modification with Physical Activity Promotion on Leptin Resistance and Quality of Life in Metabolic Syndrome - A Systematic Review with Meta-Analysis. Curr Diabetes Rev. 2021;17(3):345-355. [DOI:10.2174/1573399816666200211102917] [PubMed] [Google Scholar]
6. Dogan S, Cicekdal MB, Ozorhan U, Karabiyik G, Kazan BT, Ekici ID, et al. Roles of adiponectin and leptin signaling-related microRNAs in the preventive effects of calorie restriction in mammary tumor development. Appl Physiol Nutr Metab. 2021 Aug;46(8):866-876. [DOI:10.1139/apnm-2020-1000] [PubMed] [Google Scholar]
7. Liu L, Yan M, Yang R, Qin X, Chen L, Li L, et al. Adiponectin attenuates lipopolysaccharide-induced apoptosis by regulating the Cx43/PI3K/AKT pathway. Frontiers in Pharmacology. 2021;12. [DOI:10.3389/fphar.2021.644225] [PubMed]
8. Dhandapany PS, Kang S, Kashyap DK, Rajagopal R, Sundaresan NR, Singh R, et al. Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin. Science Advances. 2021;7(2):eabb3991. [DOI:10.1126/sciadv.abb3991] [PubMed] [Google Scholar]
9. Jumli MN, Nadeem MI. The Mechanistic and Pathophysiological Role of Adiponectin and Resistin Towards Regulation of Food Intake and Appetite in Cardiovascular Associated Risk Factor of Metabolic Syndrome. Type 2 Diabetes: IntechOpen; 2021. [Google Scholar]
10. Dundar A, Kocahan S, Sahin L. Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise training. Arch Physiol Biochem. 2021 ;127(4):291-295 [DOI:10.1080/13813455.2019.1635622] [PubMed] [Google Scholar]
11. Martinez EC, Fortes Mde S, Anjos LA. Influence of nutritional status and VO2max on adiponectin levels in men older than 35 years. [corrected]. Arq Bras Cardiol. 2011 ;96(6):471-6. English, Portuguese, Spanish. [DOI:10.1590/S0066-782X2011005000048] [PubMed] [Google Scholar]
12. Mohammad Parastesh, Ali Heidarianpour, Abbas Saremi, Mohammad Mehdi Rafiei. 2014. The effect of 12 weeks of aerobic exercise on pulmonary function and serum leptin levels in obese men. Ilam University of Medical Sciences 1. 139-146.46. [Google Scholar]
13. Abbas Saremi, Nader Shundi, Neda Bayat. 2012. The effect of aerobic exercise on serum ghrelin, leptin and sleep quality of obese overweight men. Arak University of Medical Sciences 1. 52.. [Google Scholar]
14. Amir Hossein Haghighi, Hadi Yarahmadi, Arezoo Ilderabadi, Alireza Rafieipour. 2011. The effect of an aerobic exercise course on serum ghrelin and leptin levels in middle-aged men. Medical Scholar 97. 84.سال. [Google Scholar]
15. Bijeh N, Moazami M, AHMADI A, Samadpour F, Zabihi A. Effect of 6 months of aerobic exercise training on serum leptin, cortisol, insulin and glucose levels in thin middle-aged women. 2011. [Google Scholar]
16. Khadijeh Irandoost, Dr. Farhad Rahmaninia, Dr. Hamid Mohebbi, Dr. Bahman Mirzaei, Dr. Sadegh Hassannia. 2010. The effect of aerobic exercise on plasma ghrelin and leptin concentrations in obese and normal weight women. Olympics 2. 87. [Google Scholar]
17. Ara I, Perez-Gomez J, Vicente-Rodriguez G, Chavarren J, Dorado C, Calbet JA. Serum free testosterone, leptin and soluble leptin receptor changes in a 6-week strength-training programme. Br J Nutr. 2006 ;96(6):1053-9. [DOI:10.1017/BJN20061956] [PubMed] [Google Scholar]
18. Soraya Khalili, Dr. Reza Nouri. 2013. The effect of 8 weeks of resistance training on leptin and insulin resistance index in obese girls. Hamadan University of Medical Sciences and Health Services 1. 59. [DOI:10.5171/2014.665365] [Google Scholar]
19. Abedi B *, Abbasi Bakhtiari R. 1394. The effect of 12 weeks of combined training on leptin, reactive protein (C (CRP) and insulin resistance index (HPMA-IR) in overweight men. Fayz 4. 292-301. [Google Scholar]
20. Haleem DJ, Gul S. Circulating leptin, cortisol and gender differences associated with anorexia or obesity in depression. The World Journal of Biological Psychiatry. 2020;21(3):195-202. [DOI:10.1080/15622975.2019.1648870]
21. Bagheri A , Alamai R , Khosravi A , Khosravi M. 2005. Evaluation of the relationship between leptin and risk factors for coronary heart disease in patients with type II diabetes compared with non-diabetics. Hamadan University of Medical Sciences and Health Services 4. 17.. [View at Publisher] [Google Scholar]
22. Kazemi A, Rahmati M, Eskandari F, Taherabadi S J . 2016. The effect of eight weeks of intermittent interval training on serum levels of adiponectin and insulin in overweight children. Southern Medicine 1. 37-47. [Google Scholar]
23. Balagopal P, George D, Yarandi H, Funanage V, Bayne E. Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents. J Clin Endocrinol Metab. 2005 ;90(11):6192-7. [View at Publisher] [DOI:10.1210/jc.2004-2427] [PubMed] [Google Scholar]
24. Fathei M, Hejazi K, Kiani gol M. The effect of Eight weeks aerobic training on Resistin levels and cardio respiratory fitness in sedentary middle-aged women. medical journal of mashhad university of medical sciences. 2015; 58(9): 489-497. [View at Publisher] [DOI] [Google Scholar]
25. Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, et al. Adiponectin is not altered with exercise training despite enhanced insulin action. American Journal of Physiology-Endocrinology And Metabolism. 2002; 283(4): E861-E5. [View at Publisher] [DOI:10.1152/ajpendo.00150.2002] [PubMed] [Google Scholar]
26. Jeon J-Y, Han J, Kim H-J, Park MS, Seo DY, Kwak Y-S. The combined effects of physical exercise training and detraining on adiponectin in overweight and obese children. Integrative medicine research. 2013; 2(4): 145-50. [View at Publisher] [DOI:10.1016/j.imr.2013.10.001] [PubMed] [Google Scholar]
27. Syk M, Isaksson J, Rasmusson AJ, Ekselius L, Cunningham JL. Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults. Scientific reports. 2021; 11(1): 1-10. [View at Publisher] [DOI:10.1038/s41598-021-89251-y] [PubMed] [Google Scholar]
28. Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition, Metabolism and Cardiovascular Diseases. 2010;20(8):608-17. [View at Publisher] [DOI:10.1016/j.numecd.2009.04.015] [PubMed] [Google Scholar]
29. Koh EH, Kim M, Ranjan K, Kim HS, Park H-S, Oh KS, et al. eNOS plays a major role in adiponectin synthesis in adipocytes. American Journal of Physiology-Endocrinology and Metabolism. 2010; 298(4): E846-E53. [View at Publisher] [DOI:10.1152/ajpendo.00008.2010] [PubMed] [Google Scholar]
30. Davoodi B, Zilaei Bouri S, Ahangarpor A, Zilaei Bouri M. Effects of Two Different Physical Exercises on Plasma Levels of Adiponectin and Resistin in Obese and Overweight Young Girls. J Arak Uni Med Sci. 2014; 17 (4) :27-37 [View at Publisher] [Google Scholar]
31. Mehrdad Fathi, Keyvan Hejazi, Mojtaba Kiani Gol. 1394. The effect of eight weeks of aerobic exercise on resistance levels and cardiorespiratory fitness of inactive middle-aged women. Faculty of Medicine, Mashhad University of Medical Sciences 9. 489-497..
32. Rashid Lemir, Amir and Saadatunia, Arash. (1389). The effect of two months of aerobic exercise on glucose homeostasis and cardiovascular risk factors. Scientific Journal of Yazd Shahid Sadoughi University of Medical Sciences, 19 (2), 229-219.
33. Bahia L, Aguiar LG, Villela N, Bottino D, Godoy-Matos AF, Geloneze B, et al. Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome. Clinics. 2006;61(5):433-40. [View at Publisher] [DOI:10.1590/S1807-59322006000500010] [PubMed] [Google Scholar]
34. Amir Hossein Haghighi *, Hadi Yarahmadi, Maliheh Shojaei, Mehdi Hedayati. 1392. The effect of an aerobic exercise course on serum adiponectin and resistin and anthropometric variables in obese women. Olympic 1. 61. Amir Hossein Haghighi *, Hadi Yarahmadi, Maliheh Shojaei, Mehdi Hedayati. 1392. The effect of an aerobic exercise course on serum adiponectin and resistin and anthropometric variables in obese women. Olympic 1. 61-.
35. Tofighi A, Samadian Z. Comparison of 12 Weeks Aerobic with Resistance Exercise Training on Serum Levels of Resistin and Glycemic Indices in Obese Postmenopausal Women with Type 2 Diabetes (Comparison of Two Exercise Protocols). Jundishapur Scientific Medical Journal. 2014; 12(6): 665-676. [View at Publisher] [Google Scholar]
36. Huang S-W, Seow K-M, Ho L-T, Chien Y, Chung D-Y, Chang C-L, et al. Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. FEBS letters. 2005; 579(2): 449-54. [View at Publisher] [DOI:10.1016/j.febslet.2004.12.010] [PubMed] [Google Scholar]
37. Qi Q, Wang J, Li H, Yu Z, Ye X, Hu FB, et al. Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese. Eur J Endocrinol. 2008; 159(5): 585-93. [DOI:10.1530/EJE-08-0427] [PubMed] [Google Scholar]
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