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Pandit A, Siddegowda M, Shoba K L. Evaluation of Soft Tissue Tumors by Fine Needle Aspiration Cytology and Its Correlation with Histopathology: A Retrospective Study in a Tertiary Care Center. mljgoums 2022; 16 (3) :1-6
URL: http://mlj.goums.ac.ir/article-1-1468-en.html
URL: http://mlj.goums.ac.ir/article-1-1468-en.html
1- Department of Pathology, Mandya Institute of Medical Sciences, Mandya, India , p_apoorva@ymail.com
2- Department of Pathology, Mandya Institute of Medical Sciences, Mandya, India
2- Department of Pathology, Mandya Institute of Medical Sciences, Mandya, India
Abstract: (1838 Views)
Background and objectives: Soft tissue is a non-epithelial extraskeletal tissue of the body. Soft tissue tumors (STTs) are the most commonly diagnosed neoplasms. Fine needle aspiration cytology (FNAC) is minimally invasive, quick, and a definitive diagnostic modality. Biopsy for histopathology is the gold standard method for diagnosis but is invasive. The aims of this study were to determine the utility of FNAC in the diagnosis of STTs and correlate it with histopathology and to evaluate factors that cause discrepancies between FNAC and histopathology.
Methods: This retrospective, record-based study was done on STTs received for FNAC and histopathology examinations at the Department of Pathology, MIMS, Mandya from January 2018 to June 2021.
Results: A total of 74 cases of FNAC with histopathological correlation were available. Seventy one cases (95.9%) were benign and three (4%) were malignant according to FNAC. Discordance was seen in one case of low grade myxofibrosarcoma, which was diagnosed as benign spindle cell tumor on FNAC. The sensitivity, specificity, positive predictive value, and accuracy of FNAC in diagnosing malignancy were 75%, 100%, 100%, and 98.6%, respectively.
Conclusion: Our findings indicate that FNAC is beneficial preoperatively as it differentiates between benign and malignant lesions in most cases. In the case of low grade myxofibrosarcoma, bland tumor cells led to a benign diagnosis on FNAC, but histopathology allowed sampling of a larger area of the tumor and the right diagnosis was made. Biopsy is the gold standard, but FNAC has high specificity in diagnosing malignant tumors and prevents unnecessary extensive, radical surgery for benign lesions.
Methods: This retrospective, record-based study was done on STTs received for FNAC and histopathology examinations at the Department of Pathology, MIMS, Mandya from January 2018 to June 2021.
Results: A total of 74 cases of FNAC with histopathological correlation were available. Seventy one cases (95.9%) were benign and three (4%) were malignant according to FNAC. Discordance was seen in one case of low grade myxofibrosarcoma, which was diagnosed as benign spindle cell tumor on FNAC. The sensitivity, specificity, positive predictive value, and accuracy of FNAC in diagnosing malignancy were 75%, 100%, 100%, and 98.6%, respectively.
Conclusion: Our findings indicate that FNAC is beneficial preoperatively as it differentiates between benign and malignant lesions in most cases. In the case of low grade myxofibrosarcoma, bland tumor cells led to a benign diagnosis on FNAC, but histopathology allowed sampling of a larger area of the tumor and the right diagnosis was made. Biopsy is the gold standard, but FNAC has high specificity in diagnosing malignant tumors and prevents unnecessary extensive, radical surgery for benign lesions.
Research Article: Research Article |
Subject:
Pathology
Received: 2021/12/17 | Accepted: 2022/02/12 | Published: 2022/05/14 | ePublished: 2022/05/14
Received: 2021/12/17 | Accepted: 2022/02/12 | Published: 2022/05/14 | ePublished: 2022/05/14
References
1. Weiss, Sharon W. Enzinger and Weiss's Soft Tissue Tumors. 7th ed. St. Louis :Mosby, 2020. [View at Publisher] [Google Scholar]
2. Parajuli S, Lakhey M. Efficacy of fine needle aspiration cytology in diagnosing soft tissue tumors. Journal of Pathology of Nepal. 2012 Sep 25;2(4):305-8. [DOI:10.3126/jpn.v2i4.6884] [Google Scholar]
3. Chang AE, Rosenberg SA, Glastein EJ, Antman KH: Sarcomas of soft tissues. In Cancer: Principles and Practice of Oncology 3rd edition. Edited by: Vita VD, Hellman S, Rosenberg SA. Philaldelphia: JB Lippincott;1989:1345-1398
4. Nagira K, Yamamoto T, Akisue T, Marui T, Hitora T, Nakatani T, et al. Reliability of fine‐needle aspiration biopsy in the initial diagnosis of soft‐tissue lesions. Diagnostic cytopathology. 2002; 27(6): 354-61. [View at Publisher] [DOI:10.1002/dc.10200] [PubMed] [Google Scholar]
5. Roy S, Manna AK, Pathak S, Guha D. Evaluation of fine needle aspiration cytology and its correlation with histopathological findings in soft tissue tumours. Journal of cytology. 2007; 24(1): 37. [View at Publisher] [DOI:10.4103/0970-9371.42089] [Google Scholar]
6. Bezabih M. Cytological diagnosis of soft tissue tumours. Cytopathology. 2001; 12(3): 177-83. [View at Publisher] [DOI:10.1046/j.1365-2303.2001.00317.x] [Google Scholar]
7. Beg S, Vasenwala SM, Haider N, Ahmad SS, Maheshwari V, Khan MA. A comparison of cytological and histopathological findings and role of immunostains in the diagnosis of soft tissue tumors. Journal of Cytology/Indian Academy of Cytologists. 2012 Apr;29(2):125 [View at Publisher] [DOI:10.4103/0970-9371.97154] [PubMed] [Google Scholar]
8. Soni PB, Verma AK, Chandoke RK, Nigam JS. A prospective study of soft tissue tumors histocytopathology correlation. Pathology research international. 2014;2014. [View at Publisher] [DOI:10.1155/2014/678628] [PubMed] [Google Scholar]
9. Dey P, Mallik MK, Gupta SK, Vasishta RK. Role of fine needle aspiration cytology in the diagnosis of soft tissue tumours and tumour‐like lesions. Cytopathology. 2004; 15(1): 32-7. [View at Publisher] [DOI:10.1046/j.0956-5507.2003.00102.x] [PubMed] [Google Scholar]
10. Jain V, Agarwal T. Role of FNAC in soft tissue tumors and its histopathological correlation. International Surgery Journal. 2017 Jul 24;4(8):2632-6. [View at Publisher] [DOI:10.18203/2349-2902.isj20173402] [Google Scholar]
11. Ng VY, Thomas K, Crist M, Wakely PE, Mayerson J. Fine needle aspiration for clinical triage of extremity soft tissue masses. Clinical Orthopaedics and Related Research®. 2010; 468(4): 1120-8. [View at Publisher] [DOI:10.1007/s11999-009-1100-7] [PubMed] [Google Scholar]
12. Rekhi B, Gorad BD, Kakade AC, Chinoy RF. Scope of FNAC in the diagnosis of soft tissue tumors-a study from a tertiary cancer referral center in India. Cytojournal. 2007;4:20. [DOI:10.1186/1742-6413-4-20] [PubMed] [Google Scholar]
13. Domanski HA. Fine‐needle aspiration cytology of soft tissue lesions: diagnostic challenges. Diagnostic cytopathology. 2007; 35(12): 768-73. [View at Publisher] [DOI:10.1002/dc.20765] [Google Scholar]
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