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Volume 17, Issue 3 (May-Jun 2023)
mljgoums 2023, 17(3): 55-62 |
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Balaghi Inaloo F, Askari R, Haghighi A H, kashani K, Friedemann P. Decreased Serum Neurofilament Light Chain and Fatigue Severity in Patients with Multiple Sclerosis after Home-Based and Outdoor Pilates Training. mljgoums 2023; 17 (3) :55-62
URL: http://mlj.goums.ac.ir/article-1-1544-en.html
URL: http://mlj.goums.ac.ir/article-1-1544-en.html
1- Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran , faranakbalaghi70@gmail.com
2- Department of Sports Physiology, Hakim Sabzevari University, Sabzevar, Iran
3- Neurologist, Fars Province, Fasa, Iran
4- Neurologist and Scientific Director of the Experimental and Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin, Germany
2- Department of Sports Physiology, Hakim Sabzevari University, Sabzevar, Iran
3- Neurologist, Fars Province, Fasa, Iran
4- Neurologist and Scientific Director of the Experimental and Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin, Germany
Abstract: (2185 Views)
Background and objectives: Studies have reported contradictory results regarding the relationship between serum neurofilament light chain (NFL) and fatigue severity. The aim of our study was to investigate serum NFL and fatigue severity in patients with multiple sclerosis (MS) after home-based and outdoor Pilates training.
Methods: The study population consisted of 44 women with MS (aged 25 to 40 years) with an expanded disability status scale score of 2-5. The patients were randomly divided into three groups: home-based training (HPT, n=15), outdoor training (OPT, n=15), and a control group (n=14). The training groups performed Pilates exercises for 8 weeks individually at home and under the sun. Blood samples and completed Fatigue Severity Scale forms were taken 48 hours before the first session and after the 8-week intervention.
Results: The results showed that OPT caused a more notable increase in serum vitamin D (32.76±5.13, p<0.001) and a decrease in NFL (15.98±2.26, p <0.001) and FSS score (2.51±0.35, p<0.001) compared with HPT. Also, HPT lowered NFL (18.01±2.28, p<0.001) and FSS score (3.84±0.98, p<0.001) compared with the control group.
Conclusion: Pilates training can reduce NFL levels and FSS scores in women with MS. In addition, OPT is more effective than HPT in reducing NFL and FSS and increasing vitamin D levels.
Methods: The study population consisted of 44 women with MS (aged 25 to 40 years) with an expanded disability status scale score of 2-5. The patients were randomly divided into three groups: home-based training (HPT, n=15), outdoor training (OPT, n=15), and a control group (n=14). The training groups performed Pilates exercises for 8 weeks individually at home and under the sun. Blood samples and completed Fatigue Severity Scale forms were taken 48 hours before the first session and after the 8-week intervention.
Results: The results showed that OPT caused a more notable increase in serum vitamin D (32.76±5.13, p<0.001) and a decrease in NFL (15.98±2.26, p <0.001) and FSS score (2.51±0.35, p<0.001) compared with HPT. Also, HPT lowered NFL (18.01±2.28, p<0.001) and FSS score (3.84±0.98, p<0.001) compared with the control group.
Conclusion: Pilates training can reduce NFL levels and FSS scores in women with MS. In addition, OPT is more effective than HPT in reducing NFL and FSS and increasing vitamin D levels.
Keywords: Exercise Movement Techniques [MeSH], Neurofilament Protein [MeSH], vitamin D [MeSH], fatigue [MeSH], Multiple Sclerosis [MeSH]
Research Article: Research Article |
Subject:
Sport Physiology
Received: 2022/07/2 | Accepted: 2022/08/6 | Published: 2023/05/21 | ePublished: 2023/05/21
Received: 2022/07/2 | Accepted: 2022/08/6 | Published: 2023/05/21 | ePublished: 2023/05/21
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