Volume 19, Issue 6 (Nov-Dec 2025)                   mljgoums 2025, 19(6): 16-19 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bhaskar Manalikandy M, Mohanty A, Maria Joseph N, Jaisundar Selvaraj R, Sistla S. Pacemaker pocket infection due to Mycobacterium abscessus subspecies abscessus: A Case Report and Literature Review. mljgoums 2025; 19 (6) :16-19
URL: http://mlj.goums.ac.ir/article-1-1797-en.html
1- Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
2- Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
3- Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India , sujathasistla@gmail.com
Abstract:   (660 Views)
Background: Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium that can cause various infections in humans. The identification of nontuberculous mycobacteria remains a challenge to date due to the availability of limited resources. There have been reports of device-related infections caused by these bacteria. Improper care of cardiac implants can give rise to infections that need to be identified promptly. This report emphasizes the need for early and prompt diagnosis of non-tuberculous mycobacterial infections.
Case Report: Here, we present a case of a 69-year-old man who presented with an atrioventricular block and therefore underwent pacemaker implantation. The implant became infected with Mycobacterium abscessus, which resolved after appropriate treatment and pacemaker removal.
Conclusion: Non-tuberculous mycobacteria must be promptly identified and treated for the appropriate duration to prevent complications associated with them.
Full-Text [PDF 380 kb]   (171 Downloads)    
Research Article: Case Report | Subject: Microbiology
Received: 2024/03/29 | Accepted: 2025/02/23 | Published: 2026/01/6 | ePublished: 2026/01/6

References
1. Klug D, Wallet F, Lacroix D, Marquié C, Kouakam C, Kacet S, et al. Local symptoms at the site of pacemaker implantation indicate latent systemic infection. Heart. 2004;90(8):882-6 [View at Publisher] [DOI] [PMID] [Google Scholar]
2. Döring M, Richter S, Hindricks G. The Diagnosis and Treatment of Pacemaker-Associated Infection. Dtsch Arztebl Int. 2018;115(26):445-52 [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Centers for Disease Control and Prevention. Nontuberculous mycobacteria (NTM) [Internet]. 2024 [cited 2024 Mar 23]. Available from: https://www.cdc.gov/hai/organisms/nontuberculous-mycobacteria.html [View at Publisher]
4. Radigan A, Jevert-Eichorn S. Rare case of pacemaker infection with Mycobacterium abscessus. BMJ Case Rep. 2019;12(9):e230100. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Moore M, Frerichs JB. An unusual acid-fast infection of the knee with subcutaneous, abscess-like lesions of the gluteal region; report of a case with a study of the organism, Mycobacterium abscessus, n. sp. J Invest Dermatol. 1953;20(2):133-69. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Villanueva A, Calderon RV, Vargas BA, Ruiz F, Aguero S, Zhang Y, et al. Report on an outbreak of postinjection abscesses due to Mycobacterium abscessus, including management with surgery and clarithromycin therapy and comparison of strains by random amplified polymorphic DNA polymerase chain reaction. Clin Infect Dis. 1997;24(6):1147-53 [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Griffith DE, Girard WM, Wallace RJ. Clinical features of pulmonary disease caused by rapidly growing mycobacteria. An analysis of 154 patients. Am Rev Respir Dis. 1993;147(5):1271-8. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Esther CR, Esserman DA, Gilligan P, Kerr A, Noone PG. Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis. J Cyst Fibros. 2010;9(2):117-23. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Radhakrishnan DK, Yau Y, Corey M, Richardson S, Chedore P, Jamieson F, et al. Non-tuberculous mycobacteria in children with cystic fibrosis: isolation, prevalence, and predictors. Pediatr Pulmonol. 2009;44(11):1100-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Sermet-Gaudelus I, Le Bourgeois M, Pierre-Audigier C, Offredo C, Guillemot D, Halley S, et al. Mycobacterium abscessus and children with cystic fibrosis. Emerg Infect Dis. 2003;9(12):1587-91. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Lee M-R, Cheng A, Lee Y-C, Yang C-Y, Lai C-C, Huang Y-T, et al. CNS infections caused by Mycobacterium abscessus complex: clinical features and antimicrobial susceptibilities of isolates. J Antimicrob Chemother. 2012;67(1):222-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Girgis DO, Karp CL, Miller D. Ocular infections caused by non-tuberculous mycobacteria: update on epidemiology and management. Clin Exp Ophthalmol. 2012;40(5):467-75. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Baker AW, Lewis SS, Alexander BD, Chen LF, Wallace RJ, Brown-Elliott BA, et al. Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. Clin Infect Dis. 2017;64(7):902-11. [View at Publisher] [DOI] [PMID] [Google Scholar]
14. Baker AW, Maziarz EK, Lewis SS, Stout JE, Anderson DJ, Smith PK, et al. Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes. Clin Infect Dis. 2021;72(7):1232-40. [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Lee M-R, Sheng W-H, Hung C-C, Yu C-J, Lee L-N, Hsueh P-R, et al. Mycobacterium abscessus Complex Infections in Humans. Emerg Infect Dis. 2015;21(9):1638-46. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. Thomson RM, Carter R, Tolson C, Coulter C, Huygens F, Hargreaves M. Factors associated with the isolation of Nontuberculous mycobacteria (NTM) from a large municipal water system in Brisbane, Australia. BMC Microbiol. 2013;13:89. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Leao SC, Tortoli E, Euzéby JP, Garcia MJ. Proposal that Mycobacterium massiliense and Mycobacterium bolletii be united and reclassified as Mycobacterium abscessus subsp. bolletii comb. nov., designation of Mycobacterium abscessus subsp. abscessus subsp. nov. and emended description of Mycobacterium abscessus. Int J Syst Evol Microbiol. 2011;61(Pt 9):2311-3. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Macheras E, Roux A-L, Bastian S, Cardoso Leão S, Palaci M, Sivadon-Tardy V, et al. Multilocus sequence analysis and rpoB sequencing of Mycobacterium abscessus (sensu lato) strains. J Clin Microbiol. 2011;49(2):491-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Nash KA, Brown-Elliott BA, Wallace RJ. A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. Antimicrob Agents Chemother. 2009;53(4):1367-76. [View at Publisher] [DOI] [PMID] [Google Scholar]
20. Jarlier V, Nikaido H. Permeability barrier to hydrophilic solutes in Mycobacterium chelonei. J Bacteriol. 1990;172(3):1418-23. [View at Publisher] [DOI] [PMID] [Google Scholar]
21. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175(4):367-416. [View at Publisher] [DOI] [PMID] [Google Scholar]
22. Kessler AT, Kourtis AP. Mycobacterium abscessus as a cause of pacemaker infection. Med Sci Monit. 2004;10(10):CS60-62. [View at Publisher] [PMID] [Google Scholar]
23. Cutay AM, Horowitz HW, Pooley RW, Van Horn K, Wormser GP. Infection of epicardial pacemaker wires due to Mycobacterium abscessus. Clin Infect Dis. 1998;26(2):520-1. [View at Publisher] [DOI] [PMID] [Google Scholar]
24. Dumic I, Lutwick L. Successful treatment of rapid growing mycobacterial infections with source control alone: Case series. IDCases. 2021;26:e01332. [View at Publisher] [DOI] [PMID] [Google Scholar]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.