Fri, Jun 12, 2026
1- Department of Physical Education and Sport Science, Sar.C, Islamic Azad University, Sari, Iran.
2- Department of Physical Education and Sport Science, Sar.C, Islamic Azad University, Sari, Iran. ,Hashemvarzi_tkd@yahoo.com
3- Department of Physical Education and Sport Science, BA.C, Islamic Azad University, Bandar Abbas, Iran.
2- Department of Physical Education and Sport Science, Sar.C, Islamic Azad University, Sari, Iran. ,
3- Department of Physical Education and Sport Science, BA.C, Islamic Azad University, Bandar Abbas, Iran.
Abstract: (210 Views)
Background and objectives: This study aimed to evaluate the effects of resistance training following bone marrow stem cell transplantation, a regenerative approach targeting damaged cardiac tissue, on myocardial oxidative stress markers and left ventricular function in a rat model of myocardial infarction (MI).
Methods: Sixty male Wistar rats (7–8 weeks old) were randomly assigned to six experimental groups (n=10 per group): healthy control, MI control, sham, stem cell, exercise, and exercise + stem cell. MI was induced by permanent ligation of the left anterior descending coronary artery. Stem cells (1×10⁶) were injected via the tail vein. Resistance training protocol consisted of climbing sessions performed five days per week for six weeks. Each session included three sets of five repetitions, with a one-minute rest interval between sets. Oxidative stress markers (CAT and MDA) were analyzed biochemically, and left ventricular function was assessed by echocardiography. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: MDA levels were significantly increased and CAT levels decreased in the MI group compared to controls. Resistance training and combined therapy significantly reduced MDA levels; however, CAT changes were not statistically significant. Cardiac output and ejection fraction were significantly improved in the intervention groups compared to the MI group.
Conclusion: Six weeks of resistance training after bone marrow stem cell transplantation effectively reduced oxidative stress and improved left ventricular function in MI rats. This combined approach may serve as a promising therapeutic strategy for myocardial infarction recovery.
Methods: Sixty male Wistar rats (7–8 weeks old) were randomly assigned to six experimental groups (n=10 per group): healthy control, MI control, sham, stem cell, exercise, and exercise + stem cell. MI was induced by permanent ligation of the left anterior descending coronary artery. Stem cells (1×10⁶) were injected via the tail vein. Resistance training protocol consisted of climbing sessions performed five days per week for six weeks. Each session included three sets of five repetitions, with a one-minute rest interval between sets. Oxidative stress markers (CAT and MDA) were analyzed biochemically, and left ventricular function was assessed by echocardiography. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: MDA levels were significantly increased and CAT levels decreased in the MI group compared to controls. Resistance training and combined therapy significantly reduced MDA levels; however, CAT changes were not statistically significant. Cardiac output and ejection fraction were significantly improved in the intervention groups compared to the MI group.
Conclusion: Six weeks of resistance training after bone marrow stem cell transplantation effectively reduced oxidative stress and improved left ventricular function in MI rats. This combined approach may serve as a promising therapeutic strategy for myocardial infarction recovery.
Keywords: resistance training, stem cell, oxidative stress, left ventricular function, myocardial infarction
Research Article: Research Article |
Subject:
Sport Physiology
Received: 2025/09/25 | Accepted: 2026/01/28
Received: 2025/09/25 | Accepted: 2026/01/28
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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